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Basic Sciences Investigations

Effect of NF-κβ inhibitor – dehydroxymethylepoxyquinomicin on iron isomaltoside toxicity toward peritoneal mesothelial cells

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Article: 2304647 | Received 18 Oct 2023, Accepted 08 Jan 2024, Published online: 19 Jan 2024

Figures & data

Figure 1. Expression of genes regulating expression of IL6, tPA, PAI-1, and TGFβ in mesothelial cells cultured in medium supplemented with DHMEQ 10 μg/mL (DHMEQ), IIS 15 μg/dL (Fe) or DHMEQ 10 μg/mL plus IIS 15 μg/dL (DHMEQ + Fe). Results are presented as % of control when cells were cultured in standard medium.

Figure 1. Expression of genes regulating expression of IL6, tPA, PAI-1, and TGFβ in mesothelial cells cultured in medium supplemented with DHMEQ 10 μg/mL (DHMEQ), IIS 15 μg/dL (Fe) or DHMEQ 10 μg/mL plus IIS 15 μg/dL (DHMEQ + Fe). Results are presented as % of control when cells were cultured in standard medium.

Figure 2. Secretion of IL6 (A), TGFβ (B), t-PA (C), and PAI-1(D) in mesothelial cells cultured in standard medium (control), medium supplemented with DHMEQ 10 μg/mL (DHMEQ), IIS 15 μg/dL (Fe), or DHMEQ 10 μg/mL plus IIS 15 μg/dL (DHMEQ + Fe) (p < .001) (n = 9).

Figure 2. Secretion of IL6 (A), TGFβ (B), t-PA (C), and PAI-1(D) in mesothelial cells cultured in standard medium (control), medium supplemented with DHMEQ 10 μg/mL (DHMEQ), IIS 15 μg/dL (Fe), or DHMEQ 10 μg/mL plus IIS 15 μg/dL (DHMEQ + Fe) (p < .001) (n = 9).