Figures & data
Table 1. Characteristics of ibuprofen exposed vs unexposed. Data are number (percentage) or median (25th–75th percentiles).
Figure 2. The association between ibuprofen exposure and postoperative AKI. Three different methods were used to assess the association: (1) multivariable Cox regression with time-varying ibuprofen exposure, (2) the same multivariable Cox regression model with ibuprofen exposure defined as given ibuprofen within 48 h after surgery, (3) propensity score-matching analysis. PSM, propensity-score matching.
![Figure 2. The association between ibuprofen exposure and postoperative AKI. Three different methods were used to assess the association: (1) multivariable Cox regression with time-varying ibuprofen exposure, (2) the same multivariable Cox regression model with ibuprofen exposure defined as given ibuprofen within 48 h after surgery, (3) propensity score-matching analysis. PSM, propensity-score matching.](/cms/asset/1e8a07f6-005d-40ef-afae-d9e3a49a1651/irnf_a_2318417_f0002_b.jpg)
Figure 3. Subgroup and interaction analyses for age, RACHS-1 score, CPB time, and baseline serum creatinine. Multivariable Cox regression model with time-varying ibuprofen exposure was used to assess the association of ibuprofen exposure with AKI. RACHS, Risk Adjustment for Congenital Heart Surgery; CPB, cardiopulmonary bypass; HR, hazard ratio.
![Figure 3. Subgroup and interaction analyses for age, RACHS-1 score, CPB time, and baseline serum creatinine. Multivariable Cox regression model with time-varying ibuprofen exposure was used to assess the association of ibuprofen exposure with AKI. RACHS, Risk Adjustment for Congenital Heart Surgery; CPB, cardiopulmonary bypass; HR, hazard ratio.](/cms/asset/e0318938-adbb-4f2d-a014-0e266ecd40c5/irnf_a_2318417_f0003_c.jpg)
Table 2. Incidence of AKI according to ibuprofen exposure.
Supplemental Material
Download PDF (61.1 KB)Data availability
The data of this study are available from the corresponding author, Jianhui Wang, upon reasonable request.