Probiotics and Helicobacter pylori infection

Figures & data

Table I.  Microorganisms used for probiotics.

A: Lactic acid bacteria

(1) Lactobacillus spp.

L. acidophilus

L. lactis

L. casei

L. rhamnosus

L. plantarum

L. murimnus

L. reuteri

L. brevis

(2) Leuconostoc spp.

L. mesenterioides

(3) Pediococcus spp.

P. cerevisiae

P. acidilactici

(4) Streptococcus spp.

E. faecium

E. faecalis

S. thermophilus

B: Bifidobacteria

Bifidobacterium spp.

B. pseudolongum

B. thermophilum

B. longum

B. animalis

B. breve

B. infantis

C: Yeast and moulds

Saccharomyces spp.

S. cerevisiae

S. fragilis

S. boulardii

Torulopsis spp.

Aspergillus oryzae

D: Spore formers

Bacillus spp.

B. cereus

B. toyoi

B. licheniformis

B. subtilis

Clostridium spp.

C. butyricum

E: Enterobacteriaceae

E. coli

Table II.  Effect of culture supernatants of C. butyricum strain MIYAIRI588 on the growth of H. pylori strain TK1402*.

		No. (log10 cfu/ml) of H. pylori TK1402
Composition of supernatants	pH	24 h	48 h	72 h
100%	4.8	ND	ND	ND
	7.2	3.2	ND	ND
25%	5.8	6.8	6.7	7.1
	7.2	6.3	6.8	6.9
0%	7.2	7.1	7.8	8.0

ND, not detected.

*Initial inoculum of H. pylori strain TK1402; 10^5.1 cfu/ml.

Table III.  Effect of Clostridium butyricum on H. pylori-monoassociated gnotobiotic mice.

Mouse no.	C. butyricum	Day after inoculation	H. pylori (cfu/g mucus)
1	Vegetative	0	7.6×10^4
2	Vegetative	1	1.5×10^3
3	Vegetative	7	3.5×10^2
4	Vegetative	14	1.9×10^3
5	Vegetative	21	5.0×10^2
6	Spore	1	3.1×10^4
7	Spore	7	1.5×10^3
8	Spore	14	1.0×10^2
9	Spore	21	ND
10	None	1	1.5×10^4
11	None	7	7.3×10^4
12	None	14	1.9×10^3
13	None	21	2.3×10^4

ND, not detected.

Table IV.  The effects of probiotics on H. pylori infection: in vitro and in vivo studies.

Authors (ref.)	Probiotics used
Kabir et al. [5]	L. salivarius
Aiba et al. [6]	L. salivarius
Takahashi et al. [7]	C. butyricum
Pinchuk et al. [8]	B. subtilis
Oh et al. [9]	Folk yoghurt
Nam et al [10]	Weissella confusa
Sgouras et al. [11]	L. casei
Johnson-Henry et al. [12]	L. rhamnosus + L. acidophilus

Table V.  Effect of probiotics on H. pylori infections: clinical trials.

Authors (ref.)	Probiotics used
Michetti et al. [13]	L. acidophilus
Canducci et al. [14]	L. acidophilus
Sakamoto et al. [15]	L. gasseri
Felley et al. [16]	L. johnsonii (acidified milk)
Armuzzi et al. [17]	Lactobacillus GG
Cremoniniet al. [18]	B. subtilis
Sheu et al. [19]	Lactobacillus+Bifidobacteriium
Wendakoon et al. [20]	L. acidophilus+L. casei,
	L. acidophilus+L. bulgaricus + S. thermophilus
Linsalata et al. [21]	L. brevis
Wang et al. [22]	Lactobacillus+Bifidobacterium
Nista et al. [23]	B. clausii
Trusi et al. [24]	L. casei

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