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Autoimmunity Volume 38, 2005 - Issue 4
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Heritability of levels of autoantibodies using the method of plotting regression of offspring on midparent (ROMP)

Ingrid M. Outschoorn Centro Nacional de Microbiologia, Unidad de Respuesta Inmune, Instituto de Salud Carlos III, Majadahonda, Madrid, 28220, Spain
,
Noel R. Rose Johns Hopkins Medical Institutions, Departments of Pathology and of Molecular Microbiology and Immunology, Baltimore, MD21205, USA
,
C. Lynne Burek Johns Hopkins Medical Institutions, Departments of Pathology and of Molecular Microbiology and Immunology, Baltimore, MD21205, USA
,
Tim W. Jones The University of Western Australia, Telethon Institute for Child Health Research, Centre for Child Health Research, P.O. Box 855, West Perth, WA, 6872, Australia
,
Ian R. Mackay Monash University Clayton, Department of Biochemistry and Molecular Biology, 3800, Victoria, Australia
&
Merrill J. Rowley Monash University Clayton, Department of Biochemistry and Molecular Biology, 3800, Victoria, Australia
Pages 325-326 | Received 22 Mar 2005, Accepted 30 Mar 2005, Published online: 07 Jul 2009
 
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Abstract

The genetic control of the levels of autoantibodies has rarely been examined. We examined the heritability of autoantibodies to glutamic acid decarboxylase (GAD65) in type 1 diabetes, and to thyroglobulin (Tg) in chronic lymphocytic thyroiditis and thyrotoxicosis, using regression of offspring on midparent (ROMP) methods. Levels of autoantibodies in patients and their parents were significantly correlated in thyrotoxicosis (R2 = 0.569, p = 0.001), consistent with the reported Gm association, but not in chronic lymphocytic thyroiditis or type 1 diabetes. Extension of the procedure to other autoantibody disorders could be informative.

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