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Original

Attraction of phagocytes by apoptotic cells is mediated by lysophosphatidylcholine

, , , &
Pages 342-344 | Received 07 Mar 2007, Accepted 13 Mar 2007, Published online: 07 Jul 2009
 

Abstract

Apoptotic cells promote the phagocytosis of themselves via the exposure of “eat me” signals. Furthermore, a second, “find me” signal is required to attract phagocytes. In this review the double function of lysophosphatidylcholine for the clearence of apoptotic material as factor leading to attraction of phagocytes as a soluble “find me” signal and opsonisation of apoptotic cells as a membrane bound “eat me” signal is outlined. Lysophosphatidylcholine, exerting this bivalent function, leads to a sufficient clearance of apoptotic cell as a “keep calm” mechanism to prevent activation of the immune system by secondary necrosis.

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