Serum sirtuin-1 a potential marker in the diagnosis of rheumatoid arthritis

Figures & data

Figure. 1 Comparison of eight markers among RA group, non-RA group and healthy control group.

Table 1. General information of each group.

Groups	RA(n = 210)	non-RA(n = 212)				Controls(n = 58)	P
		AS(n = 55)	OA(n = 48)	SS(n = 83)	SLE(n = 24)
Age (years)	52.87 ± 15.48	52.82 ± 14.81	55.15 ± 12.33	56.10 ± 14.33	33.92 ± 12.48	50.51 ± 15.35	0.748
Sex (F/M)	174/38	39/16	42/6	69/14	21/3	47/11	0.690

Figure 2. The ROC curves of the eight detection markers.

Table 2. Regions under the ROC curve of the eight test markers.

Marker	AUC	Standard error	Asymptotic significance	Asymptotic 95% confidence interval
				Lower limit	Upper limit
SIRT1	0.882	0.016	0.000	0.851	0.912
anti-CCP	0.912	0.014	0.000	0.885	0.939
anti-MCV	0.925	0.012	0.000	0.902	0.948
RF	0.797	0.022	0.000	0.754	0.840
HMGB1	0.802	0.020	0.000	0.764	0.840
CTHRC1	0.728	0.024	0.000	0.682	0.774
ESR	0.660	0.025	0.000	0.611	0.710
CRP	0.753	0.022	0.000	0.710	0.797

Table 3. Clinical evaluation of the eight test markers.

Marker	Cut-off value	Sensitivity (%)	Specificity (%)	-LR	+LR	NPV(%)	PPV(%)	Youden index
SIRT1	49.155	0.731	0.959	0.281	17.829	0.818	0.934	0.69
anti-CCP	2.25	0.948	0.772	0.067	4.158	0.950	0.767	0.72
anti-MCV	31.61	0.849	0.862	0.175	6.152	0.878	0.829	0.711
RF	110	0.651	0.896	0.389	6.259	0.764	0.831	0.547
HMGB1	11.885	0.632	0.791	0.465	3.024	0.731	0.705	0.423
CTHRC1	254.25	0.585	0.821	0.505	3.268	0.714	0.721	0.406
ESR	42.825	0.656	0.701	0.491	2.194	0.720	0.635	0.357
CRP	25.425	0.594	0.821	0.495	3.318	0.719	0.724	0.415

Table 4. Clinical evaluation of the combined test.

Groups	In series			In parallel
	Sensitivity (%)	Specificity (%)	Youden index	Sensitivity (%)	Specificity (%)	Youden index
SIRT1/anti-CCP	0.708	0.959	0.667	0.972	0.772	0.744
SIRT1/anti-MCV	0.698	0.959	0.657	0.882	0.862	0.744
anti-CCP/anti-MCV	0.840	0.862	0.702	0.958	0.772	0.730

Figure 3. Degree of correlation between the markers.

Data availability statement

The data that support the findings of this study are available from the corresponding author, [LT], upon reasonable request.