Erratum

Figures & data

Table 1  Incidence (# affected/# examined) of respiratory epithelial inflammation. Bold numbers denote that a statistically significant increase in the incidence of the lesion was seen (vs. air-exposed controls, p< 0.05, Pearson's). Number in parentheses indicate average severity of the lesion seen in animals with a statistically significant lesion incidence. Unaffected animals were excluded from this calculation. 1 = minimal, 2 = slight/mild, 3 = moderate, 4 = moderately severe, and 5 = severe/high). Additional examined nasal regions (see text for details) that were unaffected by acetaldehyde exposure are not included in this Table.

		Acetaldehyde concentration (ppm)
		Air					150					500					1500
		Exposure Day
Location	Level	4	9	14	30	65	4	9	14	30	65	4	9	14	30	65	4	9	14	30	65
Dorsal meatus	I	1/12	1/12	1/11	0/12	1/12	0/12	0/12	0/12	0/12	0/12	0/12	0/12	0/12	0/12	0/12	0/12	0/12	0/12	3/12	10/12 (1.5)
Lateral wall	I	1/12	0/12	0/11	0/12	0/12	0/12	0/12	0/12	0/12	0/12	1/12	0/12	1/12	0/12	0/12	3/12	1/12	9/12 (1.2)	0/12	3/12
Larynx^a		0/9	0/10	0/11	0/12	0/12	0/12	0/11	0/12	0/11	0/5	0/12	0/12	0/12	0/12	0/7	0/9	0/2	0/8	0/11	0/12
Trachea		0/12	0/12	0/12	0/12	0/12	0/11	0/12	0/12	0/12	0/12	0/12	0/12	0/12	0/12	0/12	0/11	0/10	0/12	0/12	0/12
Lung		1/12	0/12	0/12	1/12	0/12	NE	NE	NE	NE	NE	NE	NE	NE	NE	NE	1/12	0/12	1/12	0/12	0/12

NE: Not examined.

^aSome samples were lost as a result of improper gross trim and/or sectioning.

Table 2  Incidence (# affected/# examined) of respiratory epithelial hyperplasia. Bold numbers denote that a statistically significant increase in the incidence of the lesion was seen (vs. air-exposed controls, p< 0.05, Pearson's). Number in parentheses indicate average severity of the lesion seen in animals with a statistically significant lesion incidence. Unaffected animals were excluded from this calculation. 1 = minimal, 2 = slight/mild, 3 = moderate, 4 = moderately severe, and 5 = severe/high). Additional examined nasal regions (see text for details) that were unaffected by acetaldehyde exposure are not included in this Table.

		Acetaldehyde concentration (ppm)
		Air					150					500					1500
		Exposure Day
Location	Level	4	9	14	30	65	4	9	14	30	65	4	9	14	30	65	4	9	14	30	65
Dorsal meatus	Tip	0/12	1/12	0/11	0/12	0/12	0/12	0/12	0/12	2/12	1/12	2/12	312	10/12	9/12	11/12	11/12	9/12	12/12	12/12	12/12
														(1.0)	(1.0)	(1.0)	(1.5)	(1.4)	(2.0)	(1.3)	(1.1)
	I	0/12	0/12	0/11	0/12	0/12	0/12	0/12	0/12	0/12	0/12	1/12	1/12	11/12	5/12	5/12	0/12	0/12	0/12	3/12	0/12
														(1.0)	(1.0)	(1.0)
Lateral wall	II	0/12	0/12	1/11	0/12	0/12	0/12	2/12	3/12	0/12	1/12	0/12	3/12	6/12	1/12	2/12	6/12	6/12	3/12	0/12	1/12
														(1.0)			(1.0)	(1.0)
Maxilloturbinate	I	0/12	0/12	0/11	0/12	0/12	0/12	0/12	0/12	0/12	0/12	0/12	0/12	0/12	0/12	0/12	2/12	0/12	0/12	0/12	0/12
Larynx^a		0/9	0/9	0/11	0/12	0/12	0/12	0/9	0/12	0/12	0/12	0/12	0/9	0/12	0/12	0/12	0/9	0/2	0/12	0/12	0/12

^aSome samples were lost as a result of improper gross trim and/or sectioning.

Table 3  Incidence (# affected/# examined) of squamous metaplasia of the respiratory epithelium. Bold numbers denote that a statistically significant increase in the incidence of the lesion was seen (vs. air-exposed controls, p< 0.05, Pearson's). Number in parentheses indicate average severity of the lesion seen in animals with a statistically significant lesion incidence. Unaffected animals were excluded from this calculation. 1 = minimal, 2 = slight/mild, 3 = moderate, 4 = moderately severe, and 5 = severe/high). Additional examined nasal regions (see text for details) that were unaffected by acetaldehyde exposure are not included in this Table.

		Acetaldehyde concentration (ppm)
		Air					150					500					1500
		Exposure Day
Location	Level	4	9	14	30	65	4	9	14	30	65	4	9	14	30	65	4	9	14	30	65
Dorsal meatus	I	0/12	0/12	0/11	0/12	0/12	0/12	0/12	0/12	0/12	0/12	1/12	0/12	0/12	0/12	0/12	6/12	12/12	12/12	11/12	12/12
																	(1.0)	(1.5)	(1.8)	(1.7)	(1.7)
Maxilloturbinate	I	0/12	1/12	0/11	1/12	0/12	0/12	0/12	0/12	2/12	0/12	4/12	4/12	8/12	9/12	9/12	9/12	8/12	12/12	12/12	12/12
												(1.0)	(1.0)	(1.0)	(1.0)	(1.0)	(1.0)	(1.0)	(1.0)	(1.1)	(1.0)
Larynx^a		0/9	0/10	0/11	0/12	0/12	0/12	0/11	0/12	0/11	0/5	0/12	3/12	2/12	3/12	4/7	3/9	1/2	6/12	5/11	9/12
																(1.5)	(1.0)		(1.2)	(1.4)	(1.7)

^aSome samples were lost as a result of improper gross trim and/or sectioning.

Table 4  Incidence (# affected/# examined) of olfactory epithelial degeneration or vacuolation. Bold numbers denote that a statistically significant increase in the incidence of the lesion was seen (vs. air-exposed controls, p< 0.05, Pearson's). Number in parentheses indicate average severity of the lesion seen in animals with a statistically significant lesion incidence. Unaffected animals were excluded from this calculation. 1 = minimal, 2 = slight/mild, 3 = moderate, 4 = moderately severe, and 5 = severe/high; P = present). Additional examined nasal regions (see text for details) that were unaffected by acetaldehyde exposure are not included in this Table.

		Acetaldehyde concentration (ppm)
		Air					150					500					1500
		Exposure Day
Location	Level	4	9	14	30	65	4	9	14	30	65	4	9	14	30	65	4	9	14	30	65
Degeneration
Dorsal meatus	II	0/12	0/12	0/11	0/12	0/12	10/12^a	10/12^a	2/12^b	12/12^a	12/12^a	8/12	11/12	8/12^b	11/12	12/12	12/12	12/12	4/12^b	12/12	12/12
							(1.0)	(1.0)		(1.2)	(1.3)	(1.0)	(1.1)	(1.3)	(1.3)	(1.3)	(1.0)	(1.8)	(2.0)	(3.3)	(4.0)
	III	0/12	0/12	0/12	0/12	0/12	0/12	0/12	0/12	0/12	0/12	0/12	0/12	0/12	1/12	4/12	0/12	0/12	10/12	0/12	12/12
																(1.0)			(1.1)		(2.7)
Ethmoid turbinate	III	0/12	0/12	0/12	0/12	0/12	0/12	0/12	0/12	0/12	0/12	0/12	0/12	0/12	0/12	0/12	0/12	0/11	0/12	0/12	10/12
																					(2.2)
Vacuolation
Dorsal meatus	III	0/12	0/12	0/12	0/12	0/12	1/12	10/12^a	9/12^a	6/12^a	12/12^a	1/12	1/12	4/12 (P)	2/12	7/12 (P)	1/12	6/11 (P)	0/12	6/12^a	0/12
								(P)	(P)	(P)	(P)			(P)		(P)		(P)		(P)
	IV	0/12	0/12	0/12	0/12	0/12	0/12	0/12	0/12	0/12	4/12^a	0/12	0/12	0/12	1/12	5/12	0/12	0/11	0/12	0/12	5/12
											(P)					(P)					(P)

^aLesion incidence at 50 ppm = 0/12.

^bSome specimens contained little olfactory epithelium due to sectioning in a more anterior location.