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Review Article

Fungal fatal attraction: a mechanistic review on targeting liposomal amphotericin B (AmBisome®) to the fungal membrane

Pages 180-185 | Received 29 May 2017, Accepted 23 Jul 2017, Published online: 14 Aug 2017

Figures & data

Figure 1. Labelling schemes of liposomal amphotericin B preparations.

Figure 1. Labelling schemes of liposomal amphotericin B preparations.

Figure 2. Alternate modes of liposome fungal interaction with the fungal membrane involves (A) amphotericin B leaving the liposome that is perturbed by fungal well and binds to ergosterol in the fungal membrane, or (B.1) the liposome traverses through the fungal cell wall to (B.2) to fuse with the fungal cell membrane and facilitate transference of amphotericin B.

Figure 2. Alternate modes of liposome fungal interaction with the fungal membrane involves (A) amphotericin B leaving the liposome that is perturbed by fungal well and binds to ergosterol in the fungal membrane, or (B.1) the liposome traverses through the fungal cell wall to (B.2) to fuse with the fungal cell membrane and facilitate transference of amphotericin B.