Molecular mechanisms underlying the reception and transmission of sour taste information

Figures & data

Fig. 1. Schematic drawing illustrating conformational structures of Pkd1l3 and Pkd2l1.

Notes: Mouse Pkd1l3 is predicted to have 11 transmembrane domains, and contains an N-terminal CLD, 29 S/P-rich repeats, a GPS, and a LH2/PLAT domain. Note that human PKD1L3 does not contain S/P-rich repeats, even in its genomic sequences. Pkd2l1 is predicted to have six transmembrane domains and contains a putative Ca²⁺ binding EF hand motif and predicted coiled-coil domain in its C-terminal cytoplasmic tail. CLD, C-type lectin domain; S/P-rich repeats, serine/proline-rich repeats; GPS, G-protein-coupled receptor proteolytic site; PLAT, polycystin-1-lipoxygenase-alpha toxin; LH2, lipoxygenase homology 2; ER, endoplasmic recticulum retention signal; EF hand, calcium-binding domain. Portions of this Figure were modified from Fig. 1 in Delmas et al.⁴⁴⁾

Delmas P, Padilla F, Osorio N, Coste B, Raoux M, Crest M. Polycystins, calcium signaling, and human diseases. Biochem. Biophys. Res. Commun. 2004;322:1374–1383.10.1016/j.bbrc.2004.08.044

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