Figures & data
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Fig. 1. Induction of contact dermatitis.
Notes: Contact dermatitis was induced by applying DNFB or vehicle every 3 days to the right ear of mice and the temporal changes of ear thickness were measured. The results are presented as mean ± SD (n = 6).
![Fig. 1. Induction of contact dermatitis.Notes: Contact dermatitis was induced by applying DNFB or vehicle every 3 days to the right ear of mice and the temporal changes of ear thickness were measured. The results are presented as mean ± SD (n = 6).](/cms/asset/3aa1f5a6-4c93-4fbf-8182-c5f359483c02/tbbb_a_1027653_f0001_b.gif)
Fig. 2. Contents of Hyp-Gly and Pro-Hyp in mouse ear.
Notes: (A, B): Hyp-Gly (A) and Pro-Hyp (B) in the non-treated left ear of mice treated with vehicle (V) or DNFB on the right ear for 9 or 18 days. (C, D): Hyp-Gly (C) and Pro-Hyp (D) in the right ear treated with vehicle (V) or DNFB for 9 or 18 days. The results are presented as mean ± SD (n = 6). Values in the same figure not sharing a common letter above the bar are significantly different from each another, p < 0.05.
![Fig. 2. Contents of Hyp-Gly and Pro-Hyp in mouse ear.Notes: (A, B): Hyp-Gly (A) and Pro-Hyp (B) in the non-treated left ear of mice treated with vehicle (V) or DNFB on the right ear for 9 or 18 days. (C, D): Hyp-Gly (C) and Pro-Hyp (D) in the right ear treated with vehicle (V) or DNFB for 9 or 18 days. The results are presented as mean ± SD (n = 6). Values in the same figure not sharing a common letter above the bar are significantly different from each another, p < 0.05.](/cms/asset/806dac6d-e5b4-4057-9a21-67889ffc41f4/tbbb_a_1027653_f0002_b.gif)
Fig. 3. Pro-Hyp in plasma after ingestion of Pro-Hyp.
Notes: Pro-Hyp was orally administered at a dose of 400 μg/20 g body weight and measured in the plasma. The results are presented as mean ± SD (n = 3).
![Fig. 3. Pro-Hyp in plasma after ingestion of Pro-Hyp.Notes: Pro-Hyp was orally administered at a dose of 400 μg/20 g body weight and measured in the plasma. The results are presented as mean ± SD (n = 3).](/cms/asset/80a3c93a-ea6d-4a38-b811-071da0fea69f/tbbb_a_1027653_f0003_b.gif)
Fig. 4. Contents of [13C5,15N]Pro-Hyp and [13C5,15N]Pro in the ears of mice with contact dermatitis.
Notes: The right ear of mice was treated with DNFB (+) and the left ear was non-treated (−) for 18 days. On day 18, the mice were orally administered water, [13C5,15N]Pro-Hyp or [13C5,15N]Pro, and the contents of the labeled Pro-Hyp (A) and Pro (B) in each ear were determined 4 h after ingestion (n = 4). *p < 0.05.
![Fig. 4. Contents of [13C5,15N]Pro-Hyp and [13C5,15N]Pro in the ears of mice with contact dermatitis.Notes: The right ear of mice was treated with DNFB (+) and the left ear was non-treated (−) for 18 days. On day 18, the mice were orally administered water, [13C5,15N]Pro-Hyp or [13C5,15N]Pro, and the contents of the labeled Pro-Hyp (A) and Pro (B) in each ear were determined 4 h after ingestion (n = 4). *p < 0.05.](/cms/asset/2158be5e-0b7a-48ba-9d5b-00b59deca31b/tbbb_a_1027653_f0004_b.gif)