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Organic Chemistry

Synthesis and degranulation-inhibiting activities of the proposed apteniols B, C, and G

, , , , , , & show all
Pages 1743-1749 | Received 17 Apr 2015, Accepted 02 May 2015, Published online: 15 Jul 2015

Figures & data

Fig. 1. Proposed structures of apteniols A–G.

Fig. 1. Proposed structures of apteniols A–G.

Table 1. 1H and 13C NMR dataTable Footnotea for synthesized and reported apteniol G (CD3OD, 500/125 MHz).

Table 2. 1H and 13C NMR dataTable Footnotea for synthesized and reported apteniol B (CD3OD, 500/125 MHz).

Table 3. 1H and 13C NMR dataTable Footnotea for synthesized and reported apteniol C (CDCl3, 500/125 MHz).

Fig. 2. Synthesis of proposed apteniols B (2), C (3), and G (7).

Fig. 2. Synthesis of proposed apteniols B (2), C (3), and G (7).

Fig. 3. Synthesis of compounds 1014.

Fig. 3. Synthesis of compounds 10–14.

Table 4. Comparison of chemical shifts of 7- and 7ʹ-aldehyde and methoxy group.Table Footnotea

Fig. 4. Inhibitory effects of compounds on antigen-induced degranulation in RBL-2H3 cells.

Fig. 4. Inhibitory effects of compounds on antigen-induced degranulation in RBL-2H3 cells.

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