Identification of the differential expression of serum microRNA in type 2 diabetes

Figures & data

Fig. 1. Systematic overview of the workflow.

Table 1. Characteristics of study participants in the screening stages.

Characteristic	Control	T2DM	P value
Sex			>0.05
Male	32	27
Female	24	13
Age, years			>0.05
Mean	63	58.7
SD	9.49	13.5

Note: Sex of T2DM compared with control group analyzed by χ² test, and ages analyzed by t-test.

Abbreviations: T2DM, type 2 diabetes mellitus; SD, standard deviation.

Table 2. Characteristics of study participants in the selection and validation stages.

	Selection (n = 263)		Validation (n = 223)		P value
Variable	No	%	No	%
Healthy count	74		69
Age, years					>0.05
Mean	53.6		54.2
SD	10.3		10.7
Sex					>0.05
Male	36	49	30	43
Female	38	51	39	57
T2DM	189		154
Age, years					>0.05
Mean	60.8		61.1
SD	12		12.4
Sex					>0.05
Male	98	52	70	45
Female	91	48	84	55

Note: Sex of T2DM compared with control group analyzed by χ² test, and ages analyzed by t-test.

Abbreviations: T2DM, type 2 diabetes mellitus; SD, standard deviation.

Fig. 2. Relative expression levels of nine candidate miRNAs.

Notes: (A–I) Different expressions of miR-1183, miR-320c, miR-320d, miR-4530, miR-4534, and miR-3960, miR-451a, miR-4443, miR-572 were confirmed by RT-PCR in groups. Data are mean ± SEM. * indicated p < 0.05.