Herquline A, produced by Penicillium herquei FKI-7215, exhibits anti-influenza virus properties

Figures & data

Fig. 1. Structure of herquline A (1).

Table 1. Anti-influenza virus activity spectrum of 1.

Strain	Type and subtype	IC50 (μg/mL)
		1	Ribavirin	Amantadine	Zanamivir	Oseltamivir
A/PR/8/34	H1N1	10	13	60	0.00015	0.51
A/WSN/33	H1N1	>300	42	18	0.00097	0.22
A/Guizhou/54/89	H3N2	>300	60	87	0.001	N.T.
A/Aichi/2/68	H3N2	>300	38	3.7	0.01	10
B/Ibaraki/2/85	B	>300	69	>100	0.002	N.T.

Fig. 2. Inhibitory activity of 1 against influenza virus replication. Open column = control (4% CH₃OH solution); closed column = 1 treatment groups; dotted column = ribavirin treatment groups. Statistical significance of differences between control and compound treatment groups was determined using two groups two-tailed Welch’s t-test. *, #, p < 0.0001 was taken as the level of statistical significance. Each column represents the mean ± SD (n = 6–9).