Development of new antituberculosis drugs from natural products^†

^†This work is a translation of an original work in Japanese in the Japan Society for Bioscience, Biotechnology, and Agrochemistry http://doi.10.1271/kagakutoseibutsu.54.37.

Figures & data

Fig. 1. Structures of avermectin, ivermectin, and artemisinin.

Fig. 2. Structure of bedaquiline.

Fig. 3. Antituberculous drugs of natural product origin, the producing microorganisms, and the respective structures (year discovered).

Fig. 4. Structures of nitroimidazole compounds.

Fig. 5. Structures of CPZEN-45/caprazamycins and liposidomycin.

Fig. 6. Structures of A54556 A, cyclomarin A, and ilamycin A.

Fig. 7. Bacterial Clp protease and the substances that disrupt it.

Fig. 8. Mycobacterium tuberculosis cell wall biosynthesis pathway and the natural product inhibitor.