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Articles

Ferulic acid suppresses expression of tryptophan metabolic key enzyme indoleamine 2, 3-dioxygenase via NFκB and p38 MAPK in lipopolysaccharide-stimulated microglial cells

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Pages 966-971 | Received 22 Aug 2016, Accepted 06 Dec 2016, Published online: 12 Jan 2017

Figures & data

Fig. 1. TNF-α, IL-6, and NO production.

Notes: Production of inflammatory mediators in MG6 cells treated with LPS and/or FA for 24 h. (A), TNF-α; (B), IL-6; and (C), NO. Values indicate mean ± SE.
Fig. 1. TNF-α, IL-6, and NO production.

Fig. 2. IDO mRNA expression.

Notes: IDO mRNA expression in MG6 cells treated with LPS and/or FA for 24 h. Values indicate mean ± SE. *p < 0.05, **p < 0.01 vs. culture treated with LPS alone (Tukey’s test).
Fig. 2. IDO mRNA expression.

Fig. 3. Expression of proteins in NF-κB and MAPK pathways.

Notes: Protein expression in MG6 cells treated with LPS and/or FA. (A) IκBα in whole cell and NF-κB in nuclear extract. (B) p38, Erk, and JNK phosphorylation in whole cell extract.
Fig. 3. Expression of proteins in NF-κB and MAPK pathways.
Supplemental material

TBBB_1274636_Supplemental_Data.pdf

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