Figures & data
Figure 1. FOXC2-AS1 and WISP1 mRNA expression were downregulated in mice with Dox-induced cardiotoxicity than in healthy mice.
Data here show the comparisons of FOXC2-AS1 (a) and WISP1 mRNA (b) expression between mice with Dox-induced cardiotoxicity and healthy mice.Notes:*, p < 0.05.
Figure 2. FOXC2-AS1 and WISP1 mRNA expression were positively correlated in mice with Dox-induced cardiotoxicity but not in healthy mice.
Data here show the Pearson correlation coefficient analyses of the correlation between FOXC2-AS1 and WISP1 mRNA expression in mice with Dox-induced cardiotoxicity (a) and in healthy mice (b).
Figure 3. FOXC2-AS1 overexpression increased viability of cardiomyocytes under Dox treatment.
Notes: *, p < 0.05.
Figure 4. FOXC2-AS1 overexpression is likely an upstream activator of WISP1 in cardiomyocytes.
Data here show the effects of FOXC2-AS1 overexpression on WISP1 protein expression (a) and the effects of WISP1 overexpression on FOXC2-AS1 expression under Dox treatment (10 ng/mL) (b), as well as the effects of FOXC2-AS1 overexpression on WISP1 protein expression with Dox treatment (c).Notes:*, p < 0.05.
