https://orcid.org/0000-0003-4905-5320
Figures & data
Figure 1. Biosynthesis of nonproteinogenic amino acids used as building blocks of nonribosomal peptides. Biosynthesis pathways of methylproline (2) (a), α-methyl-l-serine (8) (b) and nitrotyrosine (10) (c) used as building blocks of griselimycin (1), JBIR-34 (6), −35 (7) and rufomycin (9), respectively, are shown. KG, alpha-ketoglutarate; 5,10-MTHF, 5,10-methylenetetrahydrofolate; THF, tetrahydrofolate; SC, succinate.
Figure 2. Biosynthesis of polyketides, streptazone E (11) (a), JBIR-76 (12), and −77 (13) (b) and fogacins (15–17) (c).
Figure 3. Biosynthesis of an aromatic polyketide and a polyene polyketide by type II PKS systems. Overview of biosynthetic pathways of actinorhodin (a) and ishigamide (19) (b) are shown as examples, respectively.
Figure 4. Secondary metabolite specific nitrous acid biosynthetic pathway discovered from actinobacteria and natural products synthesized by this pathway.
Figure 5. Biosynthesis of benzastatin derivatives (a) and the key reaction involved in its bicyclic ring formation (b).
