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Reconstitution of biosynthetic machinery of fungal natural products in heterologous hosts

Pages 433-444 | Received 10 Oct 2019, Accepted 31 Oct 2019, Published online: 18 Nov 2019

Figures & data

Figure 1. Outline of heterologous expression of biosynthetic genes for the production of fungal natural products.

Figure 1. Outline of heterologous expression of biosynthetic genes for the production of fungal natural products.

Figure 2. Biosynthetic pathway of representative IDT paxilline (2).

Figure 2. Biosynthetic pathway of representative IDT paxilline (2).

Figure 3. Biosynthetic pathway of highly elaborated IDTs.

Figure 3. Biosynthetic pathway of highly elaborated IDTs.

Figure 4. Fungal metabolites produced by total biosynthetic approach.

Figure 4. Fungal metabolites produced by total biosynthetic approach.

Figure 5. Two cyclization modes of bifunctional terpene synthases.

Figure 5. Two cyclization modes of bifunctional terpene synthases.

Figure 6. Unified cyclization mechanism of Clade I-terpene synthases.

Figure 6. Unified cyclization mechanism of Clade I-terpene synthases.

Figure 7. Di-/sesterterpenes produced by Clade II-terpene synthases and unusual oxidative rearrangement found in the brassicicene biosynthesis.

Figure 7. Di-/sesterterpenes produced by Clade II-terpene synthases and unusual oxidative rearrangement found in the brassicicene biosynthesis.

Figure 8. Basidiomycete metabolites obtained by heterologous expression.

Figure 8. Basidiomycete metabolites obtained by heterologous expression.

Figure 9. Biosynthetic pathway of pleuromutilin (11).

Figure 9. Biosynthetic pathway of pleuromutilin (11).

Figure 10. Biosynthetic pathway of erinacine Q (12).

Figure 10. Biosynthetic pathway of erinacine Q (12).

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