Neuroprotective effect of Annona muricata-derived polysaccharides in neuronal HT22 cell damage induced by hydrogen peroxide

Figures & data

Table 1. Monosaccharide composition of ALP.

Monosaccharide	g/100g	%
Galactose	27.2	64.3
Glucose	10.3	24.37
Mannose	4.1	9.81
Fucose	0.2	0.51
Galactosamine	0.9	0.06
Glucosamine	0.3	0.93

Figure 1. Antioxidant activity of ALP.

Figure 2. Effect of ALP on proliferation, apoptotic/necrotic cell death, and cell cycle induced by H₂O₂ treatment in HT22 cells.

Figure 3. Effects of ALP on mitochondrial membrane potential reduction, released ROS, intracellular Ca²⁺, MDA and SOD productions induced by H₂O₂-treated HT22 cells.

Figure 4. Roles of ALP against H₂O₂-induced neurotoxicity signaling, MAPKs, NF-κB, and PI3K/AKT pathways in HT22 cells.

Figure 5. Roles of ALP in Nrf2-mediated HO-1/NQO-1 pathways in H₂O₂-induced neuronal cell death.

Data availability statement

The data described in this article are openly available in the Open Science Framework at DOI:10.17605/OSF.IO/TPA6U.