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Journal of Biomaterials Science, Polymer Edition Volume 27, 2016 - Issue 18
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Articles

Poly(γ-glutamic acid) modulates the properties of poly(ethylene glycol) hydrogel for biomedical applications

Weikang HuSchool of Engineering, Sun Yat-Sen University, Guangzhou, China
,
Xiaoreng FengDepartment of Orthopedics & Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China
,
Xin LiuSchool of Engineering, Sun Yat-Sen University, Guangzhou, China;Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instruments, Sun Yat-sen University, Guangzhou, China
,
Shulin DaiSchool of Engineering, Sun Yat-Sen University, Guangzhou, China
,
Wen ZengSchool of Engineering, Sun Yat-Sen University, Guangzhou, China
,
Qing JiangSchool of Engineering, Sun Yat-Sen University, Guangzhou, China;Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instruments, Sun Yat-sen University, Guangzhou, China
,
Bin ChenDepartment of Orthopedics & Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, China
,
Changyun QuanSchool of Engineering, Sun Yat-Sen University, Guangzhou, China;Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instruments, Sun Yat-sen University, Guangzhou, ChinaCorrespondence[email protected]
,
Kang SunSchool of Engineering, Sun Yat-Sen University, Guangzhou, China;Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instruments, Sun Yat-sen University, Guangzhou, ChinaCorrespondence[email protected]
&
Chao ZhangSchool of Engineering, Sun Yat-Sen University, Guangzhou, China;Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instruments, Sun Yat-sen University, Guangzhou, ChinaCorrespondence[email protected]
 show all
Pages 1775-1787 | Received 11 May 2016, Accepted 01 Sep 2016, Published online: 02 Oct 2016
 
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Abstract

In this paper, a series of copolymer hydrogels were fabricated from methacrylated poly(γ-glutamic acid) (mPGA) and poly(ethylene glycol) diacrylate (PEGDA). The effect of ionic strength and pH on the swelling behavior and mechanical properties of these hydrogels were studied in detail. Release of Rhodamine B as a model drug from the hydrogel was evaluated under varied pH. In vitro photoencapsulation of bovine cartilage chondrocytes was performed to assess the cytotoxicity of this copolymer hydrogel. The results revealed that the copolymer hydrogel is ionic- and pH-sensitive, and does not exhibit acute cytotoxicity; this copolymer hydrogel may have promising application as matrix for controlled drug release and scaffolding material in tissue engineering.

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