Inulin: a multifaceted ingredient in pharmaceutical sciences

Abstract

Inulin, a naturally occurring polysaccharide derived from plants such as chicory root, has emerged as a significant ingredient in pharmaceutical sciences due to its diverse therapeutic and functional properties. This review explores the multifaceted applications of inulin, focusing on its chemical structure, sources, and mechanisms of action. Inulin’s role as a prebiotic is highlighted, with particular emphasis on its ability to modulate gut microbiota, enhance gut health, and improve metabolic processes. The review also delves into the therapeutic applications of inulin, including its potential in managing metabolic health issues such as diabetes and lipid metabolism, as well as its immune-modulating properties and benefits in gastrointestinal health. Furthermore, the article examines the incorporation of inulin in drug formulation and delivery systems, discussing its use as a stabilizing agent and its impact on enhancing drug bioavailability. Innovative inulin-based delivery systems, such as nanoparticles and hydrogels, are explored for their potential in controlled release formulations. The efficacy of inulin is supported by a review of clinical studies, underscoring its benefits in managing conditions like diabetes, cardiovascular health, and gastrointestinal disorders. Safety profiles, regulatory aspects, and potential side effects are also addressed. This comprehensive review concludes with insights into future research directions and the challenges associated with the application of inulin in pharmaceutical sciences.

Keywords:

• Inulin
• gut microbiota
• metabolic health
• controlled release

Authors’ contributions

RT, PS, SRSR designed and optimizes the study and developed the methodology. RT, PS, SRSR performed the experiments, collection and interpretation data. PKP, VK and SR wrote the manuscript. KV contributed to manuscript revision and provided supervision. RT, PS, SRSR, PKP, VK, SR and KV read and approved the final manuscript.

Availability of data and materials

The datasets of information were collected from different sources during current study. These datasets are available from the corresponding author on reasonable request.

Disclosure statement

The authors declare that they have no conflict of interest.

Additional information

Funding

This work didn’t receive any fund from any source.