Bilateral Marginal Corneal Infiltrates: A Novel Ocular Manifestation of DRESS Syndrome

ABSTRACT

Background

Drug reaction with eosinophilia and systemic symptoms, known as DRESS syndrome, is a rare drug induced hypersensitivity reaction syndrome.

Methods

case resport.

Results

We describe a patient who presented with acute erythematous rash on her face, fever>38ºC, lymphadenopathy, blood abnormalities, and reaction suspected to be amoxicillin clavulanate-related. The patient also had an associated bilateral redness of the conjunctiva, peripheral corneal infiltrates, and anterior chamber with 3+ cells.

Conclusion

We describe the first occurrence of bilateral marginal corneal infiltrates and acute anterior uveitis associated with amoxicillin clavulanate-induced DRESS syndrome and discuss its pathogenesis.

KEYWORDS:

• Amoxicillin clavulanate
• anterior uveitis
• catarrhal infiltrates
• dress syndrome
• drug reaction
• marginal corneal infiltrates

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Statement of Ethics

Verbal and written informed consent was obtained from the patient for publication of this case report and all accompanying images.