ABSTRACT
Purpose
To describe a rare case of intraocular lymphoma that metastasized from cutaneous mycosis fungoides and transformed to large cell T cell lymphoma resulting in vitreoretinal pathology.
Methods
Retrospective case report.
Results
A 57-year-old male presented with 3 months of blurred vision in the right eye. He reported only a medical history of psoriasis. Examination revealed keratic precipitates and dense vitritis in the right eye. He was taken for a diagnostic vitrectomy. Histopathology showed that atypical lymphoid cells and flow cytometry were consistent with transformed large cell T-cell lymphoma. During follow-up, pre- and inner retinal lesions were noted throughout the posterior pole. Histopathology of the psoriatic lesions was consistent with mycosis fungoides. He was initiated on systemic and intravitreal methotrexate with improvement in vision.
Conclusions
Ocular involvement in metastatic transformed T-cell lymphoma is extremely rare but can be present with vitritis and retinal deposits. Our patient responded well to intravitreal methotrexate therapy.
Author’s contributions
David Sarraf: Consultant for Amgen, Bayer Healthcare, Genentech, Novartis, and Optovue and receives research or financial support from Allergan, Genentech, Heidelberg, Optovue, and Regeneron (Tarrytown, New York)
Brian Marr: Consultant for Aura Biosciences
Yasha Modi: Consultant to Alimera, Allergan, Thea, and Zeiss
Disclosure statement
No potential conflict of interest was reported by the author(s).