ApoB, non-HDL-C, and LDL-C Are More Prominent in Retinal Artery Occlusion Compared to Retinal Vein Occlusion

Figures & data

Table 1. Characteristics of patients with retinal artery occlusion (RAO) and control.

	RAO (n = 82)	Control (n = 82)	P value
Gender (male%)	54 (65.9)	52 (63.4)	0.744
Age (years)	58.8 ± 11.7	58.8 ± 18.1	0.148
Hypertension (%)	38 (46.3)	37 (45.1)	0.875
Diabetes (%)	14 (17.1)	6 (7.3)	0.056
Current Smokers (%)	11 (13.4)	11 (13.4)	1.000
Current Drinkers (%)	6 (7.3)	5 (6.1)	0.755
Neutrophil (×10^9/L)	3.82 ± 1.61	3.39 ± 1.20	0.203
Lymphocyte (×10^9/L)	1.89 ± 0.64	2.00 ± 0.74	0.328
Monocyte (×10^9/L)	0.49 ± 0.17	0.48 ± 0.18	0.929
TG (mmol/L)	2.19 ± 1.50	1.83 ± 1.56	0.009
TC (mmol/L)	4.91 ± 1.00	4.61 ± 0.87	0.068
HDL-C (mmol/L)	1.08 ± 0.30	1.22 ± 0.38	0.010
Non-HDL-C (mmol/L)	3.83 ± 0.93	3.38 ± 0.84	0.002
LDL-C (mmol/L)	2.89 ± 0.90	2.63 ± 0.74	0.083
Apo A1 (g/L)	1.21 ± 0.24	1.27 ± 0.25	0.167
Apo B (g/L)	0.92 ± 0.24	0.82 ± 0.19	0.005
Lp (a) (g/L)	207.08 ± 204.18	194.67 ± 205.21	0.536

RAO: Retinal artery occlusion; TG: Triglycerides; TC: Total cholesterol; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol; ApoA1: apolipoprotein A1; ApoB: Apolipoprotein B.

Figure 1. Receiver operating characteristics curve (ROC) analysis of key lipid parameters for retinal artery occlusion.

Table 2. Receiver operator characteristic (ROC) curve analysis for lipid profiles in different groups.

Index	RAO versus Control							RVO versus Control							RAO versus RVO
	AUC	95%CI	P value	Cut-off	Sensibility (%)	Specificity (%)		AUC	95%CI	P value	Cut-off	Sensibility	Specificity		AUC	95%CI	P value	Cut-off	Sensibility	Specificity
TG	0.620	0.541–0.695	0.006	>1.3	78.1	47.6		0.539	0.466–0.612	0.348	>1.24	61.1	49.5		0.633	0.557–0.704	0.002	>1.54	68.3	55.8
Non-HDL-C	0.640	0.561–0.713	0.001	>3.72	58.5	69.5		0.522	0.448–0.595	0.608	≤4.07	86.3	24.2		0.668	0.593–0.737	<0.0001	>3.73	58.5	73.7
LDL-C	0.579	0.499–0.655	0.077	>2.53	68.3	45.1		0.505	0.431–0.578	0.915	≤3.26	86.3	23.2		0.606	0.530–0.679	0.013	>2.96	45.1	73.7
Apo A1	0.563	0.483–0.640	0.165	≤1.28	75.6	43.9		0.732	0.663–0.794	<0.0001	≤1.35	75.8	67.4		0.565	0.489–0.640	0.134	≤1.19	53.7	61.1
Apo B	0.628	0.550–0.703	0.003	>0.88	59.8	62.2		0.536	0.462–0.608	0.394	>0.61	87.4	24.2		0.652	0.577–0.722	0.0003	>0.95	47.6	81.1

RAO: Retinal artery occlusion; RVO: Retinal vein occlusion; AUC: Area under curve; CI: Confidence interval; TG: Triglycerides; TC: Total cholesterol; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol; ApoA1: apolipoprotein A1; ApoB: Apolipoprotein B.

Table 3. Logistic regression analysis of independent lipid profile for identification of retinal vascular occlusions.

Lipid profile	RAO versus Control		RVO versus Control		RAO versus RVO
	OR, 95%CI	P value*	OR, 95%CI	P value*	OR, 95%CI	P value*
TG	1.18 (0.94–1.48)	0.16	0.93 (0.73–2.29)	0.59	1.61 (1.15–2.23)	0.005
Non-HDL-C	1.87 (1.27–2.75)	0.001	0.93 (0.67–1.29)	0.67	1.91 (1.29–2.82)	0.001
LDL-C	1.69 (1.06–2.39)	0.03	0.92 (0.63–1.34)	0.66	1.69 (1.13–2.52)	0.01
Apo A1	0.32 (0.08–1.29)	0.11	0.02 (0.004–0.10)	<0.0001	0.50 (0.14–1.86)	0.30
Apo B	11.72 (2.42–56.74)	0.002	1.45 (0.31–6.74)	0.64	12.12 (2.56–57.40)	0.002

*Adjusted for age, sex, hypertension, diabetes, and smoking status.

RAO: Retinal artery occlusion; RVO: Retinal vein occlusion; OR: Odds ratios; CI: Confidence interval; TG: Triglycerides; TC: Total cholesterol; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol; ApoA1: apolipoprotein A1; ApoB: Apolipoprotein B.

Table 4. Characteristics of patients with retinal vein occlusion (RVO) and control.

	RVO (n = 95)	Control (n = 95)	P
Gender (male)	57 (60.0)	54 (56.8)	0.659
Age (years)	58.7 ± 12.3	54.7 ± 20.7	0.813
Hypertension (%)	48 (50.5)	35 (36.8)	0.057
Diabetes (%)	18 (19.0)	16 (16.8)	0.705
Current Smoker (%)	10 (10.5)	11 (11.6)	0.817
Current Drinker (%)	4 (4.2)	8 (8.4)	0.233
Neutrophil (×10^9/L)	3.43 ± 1.10	3.52 ± 1.19	0.647
Lymphocyte (×10^9/L)	1.91 ± 0.59	2.27 ± 1.19	0.121
Monocyte (×10^9/L)	0.44 ± 0.12	0.50 ± 0.17	0.010
PLT (×10^9/L)	214.89 ± 61.66	242.52 ± 76.26	0.020
TG (mmol/L)	1.64 ± 0.87	1.70 ± 1.43	0.349
TC (mmol/L)	4.48 ± 0.89	4.61 ± 0.97	0.219
HDL-C (mmol/L)	1.14 ± 0.36	1.22 ± 0.35	0.072
Non-HDL-C (mmol/L)	3.33 ± 0.83	3.39 ± 0.91	0.607
LDL-C (mmol/L)	2.59 ± 0.76	2.61 ± 0.82	0.914
Apo A1 (g/L)	1.25 ± 0.24	1.46 ± 0.28	<0.0001
Apo B (g/L)	0.82 ± 0.20	0.79 ± 0.20	0.394

RVO: Retinal vein occlusion; TG: Triglycerides; TC: Total cholesterol; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol; ApoA1: apolipoprotein A1; ApoB: Apolipoprotein B.

Figure 2. Receiver operating characteristics curve (ROC) analysis of key lipid parameters for retinal vein occlusion.

Table 5. Characteristics of patients with retinal artery occlusion (RAO) and retinal vein occlusion (RVO).

	RAO (n = 82)	RVO (n = 95)	P
Gender (male)	54 (65.9)	57 (60.0)	0.422
Age (years)	58.8 ± 11.7	58.7 ± 12.3	0.978
Hypertension (%)	38 (46.3)	48 (50.5)	0.875
Diabetes (%)	14 (17.1)	18 (19.0)	0.747
Current Smoker (%)	11 (13.4)	10 (10.5)	0.554
Current Drinker (%)	6 (7.3)	4 (4.2)	0.372
Neutrophil (×10^9/L)	3.82 ± 1.61	3.43 ± 1.10	0.250
Lymphocyte (×10^9/L)	1.89 ± 0.64	1.91 ± 0.59	0.539
Monocyte (×10^9/L)	0.49 ± 0.17	0.44 ± 0.12	0.044
PLT (×10^9/L)	211.59 ± 62.4	214.89 ± 61.66	0.724
TG (mmol/L)	2.19 ± 1.50	1.64 ± 0.87	0.004
TC (mmol/L)	4.91 ± 1.00	4.48 ± 0.89	0.003
HDL-C (mmol/L)	1.08 ± 0.30	1.14 ± 0.36	0.198
Non-HDL-C (mmol/L)	3.83 ± 0.93	3.33 ± 0.83	0.0002
LDL-C (mmol/L)	2.89 ± 0.90	2.59 ± 0.76	0.016
Apo A1 (g/L)	1.21 ± 0.24	1.25 ± 0.24	0.136
Apo B (g/L)	0.92 ± 0.24	0.82 ± 0.20	0.001

RAO: Retinal artery occlusion; RVO: Retinal vein occlusion; TG: Triglycerides; TC: Total cholesterol; HDL-C: High-density lipoprotein cholesterol; LDL-C: Low-density lipoprotein cholesterol; ApoA1: apolipoprotein A1; ApoB: Apolipoprotein B.