Novel adipokines WISP1 and betatrophin in PCOS: relationship to AMH levels, atherogenic and metabolic profile

Abstract

Objective: To determine the levels of WISP1 and betatrophin in normal weight and obese women with polycystic ovary syndrome (PCOS) and to assess their relationship with anti-Müllerian hormone (AMH) levels, atherogenic profile and metabolic parameters

Methods: In this prospective cross-sectional study, the study group was composed of 49 normal weighed and 34 obese women with PCOS diagnosed based on the Rotterdam criteria; 36 normal weight and 26 obese age matched non-hyperandrogenemic women with regular menstrual cycle. Serum WISP1, betatrophin, homeostasis model assessment of insulin resistance (HOMA-IR) and AMH levels were evaluated. Univariate and multivariate analyses were performed between betatrophin, WISP1 levels and AMH levels, metabolic and atherogenic parameters.

Results: Serum WISP1 and betatrophin values were elevated in the PCOS group than in the control group. Moreover, serum WISP1 and betatrophin levels were higher in the obese PCOS subgroup than in normal weight and obese control subgroups. Multivariate analyses revealed that Body mass index, HOMA-IR, AMH independently and positively predicted WISP1 levels. Serum betatrophin level variability was explained by homocysteine, HOMA-IR and androstenedione levels.

Conclusion: WISP1 and betatrophin may play a key role on the pathogenesis of PCOS.

Chinese abstract

目的: 分别检测正常体重和肥胖的多囊卵巢综合征 (PCOS) 患者体内的WISP1及促代谢因子水平, 并评估其与抗苗勒氏管激素 (AMH) 水平、致动脉粥样硬化性和代谢参数的关系。

方法: 此前瞻性横断面研究由符合鹿特丹PCOS诊断标准的49名正常体重女性和34名肥胖女性以及有规律月经周期的36名正常体重和26名肥胖与年龄相符的非高雄激素女性。对血清WISP1、促代谢因子、稳态胰岛素评估指数 (HOMA-IR) 和AMH水平进行评估。将促代谢因子、WISP1水平与AMH水平、代谢和动脉粥样硬化参数之间进行单变量和多变量分析。

结果: PCOS组血清WISP1和促代谢因子水平均高于对照组。此外, PCOS的肥胖亚组血清WISP1和促代谢因子水平高于正常体重组和肥胖对照亚组。多变量分析显示, 体重指数、HOMA-IR、AMH水平能独立且积极地预测WISP1水平。同型半胱氨酸、HOMA-IR和雄烯二酮水平可解释血清促代谢因子水平多样性。

结论: WISP1和促代谢因子在PCOS的发病机制中可能发挥关键作用。

Keywords:

• AMH
• betatrophin
• insulin resistance
• polycystic ovary syndrome
• WISP1

Declaration of interest

None of the authors has any conflict of interest relative to this work.