The molecular and genetic aspects of adolescent girls anomalous uterine bleeding: the role of endothelial dysfunction syndrome

Figures & data

Table 1. NOS3 and ESR1 genotypes frequencies distribution in LBW girls with AUB (Group 1) and control group girls (general model).

	Frequencies
Genotype	Group 1	Control	χ^2	p	OR	95% CI
ESR1 351 AA	0.556	0.500	0.75	0.69	1.25	0.74	2.10
ESR1 351 AG	0.407	0.500			0.69	1.65	0.29
ESR1 351 GG	0.037	0.000			–	–	–
ESR1 397 TT	0.462	0.286	1.97	0.37	2.14	0.71	6.44
ESR1 397 TG	0.500	0.714			0.40	1.50	0.11
ESR1 397 GG	0.038	0.000			–	–	–
NOS3 786 TT	0.069	0.357	5.78	0.046	0.13	0.72	0.02
NOS3 786 TC	0.483	0.357			1.68	1.09	2.60
NOS3 786 CC	0.448	0.286			2.03	1.12	3.68
NOS3 894 GG	0.517	0.571	0.52	0.77	0.80	1.49	0.43
NOS3 894 GT	0.448	0.357			1.46	0.50	4.26
NOS3 894 TT	0.034	0.071			0.46	4.01	0.05

Table 2. NOS3 and ESR1 genes alleles frequencies distribution in girls with AUB (Groups 1 and 2) and in girls of control group (recessive model).

		Frequencies
Groups	Genes	AUB girls	Control group	χ^2	p	OR	95% CI
Group 1 in comparison with control group	ESR1 351 A	0.759	0.750	0.01	0.93	1.05	0.36	3.08
	ESR1 351 G	0.241	0.250			0.95	2.79	0.32
	ESR1 397 T	0.712	0.643	0.40	0.53	1.37	0.51	3.70
	ESR1 397 G	0.288	0.357			0.73	1.97	0.27
	NOS3 786 T	0.310	0.536	4.06	0.04	0.39	0.99	0.15
	NOS3 786 C	0.690	0.464			2.56	1.01	6.50
	NOS3 894 G	0.741	0.750	0.01	0.93	0.96	2.74	0.33
	NOS3 894 T	0.259	0.250			1.05	0.37	3.00
Group 2 in comparison with control group	ESR1 351 A	0.844	0.750	0.82	0.37	1.80	0.49	6.60
	ESR1 351 G	0.156	0.250			0.56	2.04	0.15
	ESR1 397 T	0.781	0.600	2.39	0.12	2.38	0.78	7.31
	ESR1 397 G	0.219	0.400			0.42	1.29	0.14
	NOS3 786 T	0.250	0.536	5.16	0.02	0.29	0.86	0.10
	NOS3 786 C	0.750	0.464			3.46	1.16	10.34
	NOS3 894 G	0.813	0.750	0.34	0.56	1.44	0.41	5.07
	NOS3 894 T	0.188	0.250			0.69	2.43	0.20

Table 3. NOS3 and ESR1 genotypes frequencies distribution in girls with AUB (Groups 1 and 2) and in girls of control group (dominant model).

	Frequencies
Genotype	AUB girls	Control group	χ^2	p	OR	95% CI
ESR1 351 AA	0.688	0.500	1.09	0.30	2.20	0.47	10.31
ESR1 351 AG + GG	0.313	0.500			0.45	2.13	0.10
ESR1 397 СС	0.625	0.267	4.01	0.04	4.58	0.97	21.68
ESR1 397 TС + ТТ	0.375	0.733			0.22	1.03	0.05
NOS3 786 TT	0.063	0.357	4.05	0.04	0.12	1.04	0.01
NOS3 786 TC + CC	0.938	0.643			8.33	0.96	72.10
NOS3 894 GG	0.625	0.571	0.09	0.77	1.25	0.27	5.77
NOS3 894 GT + GG	0.375	0.429			0.80	3.69	0.17