Reproductive dysfunctions in viral hepatitis

Figures & data

Table 1. Pathology structure of female reproductive system with HBV- and HCV-infection (n =47).

Clinical signs	abs	%
Menstrual irregularities:	33	73.3
- Polymenorrhea	7	15.6
- Algomenorrhea	5	11.1
- Opso/oligo/spaniomenorrhea	9	20.0
- Amenorrhea	12	26.6
Salpingo-oophoritis	14	31.1
Adhesive process in lower pelvis	5	11.1
Ovarian cysts	9	20.2
Diffuse mastopathy	5	11.1
Cervical erosion	3	6.7
Secondary infertility	6	13.3
Endometriosis	5	11.1
Hysteromyoma	7	15.6
Ectopic pregnancy	4	8.9
Habitual miscarriage	15	31.9

Table 2. Relative count of lymphocyte subpopulations in women associated with HBV- and HCV-infections (M ± m).

Measure %	Control n = 30	Undisturbed RF, n = 27	Miscarriage n = 15	Infertility n = 5
Lymphocytes	37.0 ± 7.3	45.9 ± 9.6	43.1 ± 6.0	44.8 ± 5.4
CD3+	54.8 ± 3.2	25.9 ± 6.9*	33.3 ± 11.7	29.2 ± 3.4*
CD4+	39.9 ± 3.3	22.1 ± 5.0*	28.4 ± 7.9	23.2 ± 3.4*
CD8+	23.9 ± 2.8	19.7 ± 6.8	23.3 ± 6.4	25.0 ± 9.6
CD16+	10.9 ± 2.6	15.2 ± 6.4	17.2 ± 7.0	17.0 ± 4.0
CD20+	10.1 ± 3.0	14.2 ± 4.9	14.5 ± 7.4	12.0 ± 2.8
CD11b+	10.8 ± 2.2	13.1 ± 3.4	15.0 ± 3.3	10.3 ± 3.6
CD95+	6.8 ± 1.1	11.1 ± 3.6	13.5 ± 4.6	8.4 ± 4.3
CD25+	1.3 ± 0.1	10.3 ± 3.3*	11.0 ± 4.6*	5.5 ± 5.0
CD56+	16.5 ± 1.0	19.9 ± 7.7	22.5 ± 9.8	16.0 ± 15.0
HLA-DR+	5.3 ± 0.6	13 ± 3.4*	14.6 ± 4.7	14.5 ± 5.5

*Disparities with control are reliable with p ≤ 0.05.

Table 3. Absolute content of lymphocyte subpopulations in women associated with HBV- and HCV-infection (M ± m).

Measure ×10^6/l	Control n = 30	Undisturbed RF, n =27	Miscarriage n =15	Infertility n = 5
Lymphocytes	2500 ± 900	2800 ± 900	3000 ± 900	2500 ± 600
CD3+	1359 ± 45.5	771.2 ± 372.5	919.0 ± 397.5	743.4 ± 214.0*
CD4+	1005 ± 39.9	630.3 ± 242.3	776.9 ± 273.1	578.0 ± 125.7*
CD8+	607.2 ± 27.6	559.8 ± 243.7	630.0 ± 200.1	617 ± 260.9
CD16+	274.0 ± 27.4	448.2 ± 221.7	477.5 ± 227.2	416.6 ± 102.4
CD20+	256.1 ± 23.4	426.7 ± 216.3	402.9 ± 215.7	279.2 ± 32.6
CD11b+	266.7 ± 55.6	402.2 ± 175.3	397.9 ± 115.6	261.8 ± 67.9
CD95+	166.7 ± 27.8	319.9 ± 139.6	364.3 ± 159.0	238.1 ± 23.8*
CD25+	3.4 ± 0.2	271.0 ± 99.7*	292.7 ± 144.3*	130.9 ± 68.9
CD56+	425.0 ± 9.3	559.4 ± 261.6	622.0 ± 325.2	263.3 ± 235.8
HLA-DR+	107.0 ± 5.7	333.1 ± 83.7*	407.8 ± 162.2	284.6 ± 37.4*

*Disparities with control are reliable with p ≤ 0.05.

Figure 1. Correlation between lymphocyte subpopulation patterns in fertile female patients.

Figure 2. Correlation between lymphocytes subpopulation patterns in patients with miscarriage.

Figure 3. Correlation between lymphocyte subpopulation patterns in infertile female patients.