Toward optimal set of single nucleotide polymorphism investigation before IVF

Figures & data

Table 1. SNP tested and the genotypes frequencies identified.

No.	Physiological group	Gene	SNP	Frequency in the population, % (database)	Frequency in the sample, %	Frequency in control, %	Number of studies (control always = 46)	OR (95% CI)
1	Thrombophilia factors	FII	20210 G > A	1.5–2.2	2.64	1.09	550	2.46
2		FV	R506Q G > A	1.5–2.2	3.64	0	550	7.07
3		PAI-I	−675 5G > 4G	30–50	47.8	31.3	502	2.09
4		ITGB3	L33P T > C	12	18	14.3	502	1.42
5		FGB	−455 G > A	7–24	29.1	22.8	398	1.16
6		ITGA2	807 C > T	15–20	42.8	29.5	430	2.36
7		GP1BA	T154M C > T	6.6–16	12	10.8	347	1.12
8		FVII	10976 G > A	5–14	7.4	8.8	126	0.89
9			−323 ins 10 bp	3–5	3.1	4.9	98	0.72
10		FXIII	V34L G > T	10–15	13	18.2	54	0.74
11		EDN1	K198N G > T	30–40	31.6	29.7	126	1.18
12		P2RY12	H1/H2	16	12.4	11.9	90	1.06
13		NOS3	894 G > T	30–40	25.8	22.0	112	1.20
14		CRP	3872 C > T	33	30	28.2	52	1.14
1	Folic acid cycle	MTR	2756 A > G	19–25	26.8	27.2	550	0.98
2		MTRR	66 A > G	39–49	58.4	42.4	550	1.9
3		MTHFR	667 C > T	32–40	41.3	18.5	550	3.1
4			1298 A > C	23–29	26.7	21.7	238	1.31
5		MTHFD1	1598 G > A	15–30	15.4	14.1	52	1.1
6		SLC19A	80 A > G	25–32	18.3	18.5	52	0.99
1	Renin-angiotensin system	AGT	T174M C > T	10–15	12	12.7	197	0.92
2			M235T T > C	34–43	38.4	27.8	197	1.44
3		AGTR1	−1166 A > C	17–30	33.3	28.5	197	1.39
4		ACE	Alu Ins/Del	45–55	52	41	98	1.18
1	Detoxification system	GSTP	I105V A > G	33.62	42.5	37.0	126	1.26
2			A114V C > T	5.12	8.7	9.8	144	0.88
3		PON1	Q192R A > G	20–30	22.6	19.4	144	1.07
1	Janus kinase	JAK2	V617F G > T	0.20	0	0	74	0.62

Table 2. Final SNP testing panel.

No.	Gene	SNP
1	FII	20210 G > A
2	FV	R506Q G > A
3	PAI-I	−675 5G > 4G
4	ITGB3	L33P T > C
5	ITGA2 or FGB	807 C > T
		−455 G > A
6	MTR	2756 A > G
7	MTRR	66 A > G
8	MTHFR	667 C > T