Abstract
This prospective cohort study was conducted on 80 patients with clomiphene citrate (CC)-resistant polycystic ovary syndrome undergoing laparoscopic ovarian drilling (LOD). Pre- and post-LOD ovarian reserve parameters (anti-Mullerian hormone: AMH, ovarian volume: OV, and antral follicle count: AFC) and ovarian stromal blood flow indices (Vascularization index: VI, flow index: FI, and vascularization flow index: VFI) were measured to explore the effect of LOD and to find out the correlation between serum AMH and different clinical, hormonal, and ultrasonic variables. There was a highly significant reduction of the serum AMH (p < .001) after LOD with significant reduction in OV, AFC and vascular indices (VI, FI and VFI) of the right and left ovaries (p < .05). LOD significantly reduced ovarian reserve parameters (AMH, OV and AFC) and ovarian stromal blood flow indices (VI, FI and VFI) with no observed correlation between AMH levels and Doppler indices.
Chinese abstract
这项前瞻性队列研究是对80名接受腹腔镜卵巢打孔术(LOD)的克罗米芬(CC)抵抗多囊卵巢综合征患者进行的。检测LOD前后卵巢储备参数(抗苗勒管激素:AMH、卵巢体积:OV和窦卵泡计数:AFC)和卵巢基质血流指数(血管化指数:VI、血流指数:FI和血管化血流指数:VFI),以探索LOD的作用并找出血清AMH与不同临床、激素和超声变量之间的相关性。LOD后血清AMH显著降低(p <.001), 右侧和左侧卵巢的OV、AFC和血管指数(VI, FI和VFI)显著降低(p <.05)。LOD显著降低卵巢储备参数(AMH、OV和AFC)和卵巢基质血流指数(VI、FI和VFI), AMH水平和多普勒指数之间没有观察到相关性。
Acknowledgments
The authors would like to thank members of the operating room and clinical Pathology laboratories at Menoufia university Hospital.
Disclosure statement
No potential conflict of interest was reported by the authors.