Elevation of progesterone on the trigger day exerts no carryover effect on live birth in freeze-all cycles

Abstract

Aim

To evaluate the effect of trigger day progesterone (P) levels on live birth in freeze-all cycles.

Material and methods

Retrospective analysis of 1034 freeze-all female patients aged <38 years with single blastocyst transfers. Patients with (n = 268) or without (n = 766) preimplantation genetic test for aneuploidy (PGT-A) arm were further categorized into three subgroups based on trigger day P levels; low (<0.80 ng/ml), medium (0.8–1.49 ng/ml), and high (≥1.50 ng/ml).

Results

Estradiol (E2) levels on trigger day, the number of oocytes retrieved and the number of mature oocytes increased significantly with increasing serum p values in cycles without and with PGT-A arms. Significant correlation was found between E2 levels on trigger day and serum P levels and between the number of total oocytes retrieved and serum P levels Live birth rates were similar in the three subgroups in without PGT-A arm (51%, 52.6%, and 51.5%, respectively; p = .922) and with PGT-A arm (55.1%, 55.1%, and 62.5%, respectively; p = .730). Multivariate regression analysis revealed that trigger day P levels were not significant for live birth.

Conclusion

The proposal that trigger day progesterone elevation (PE) exerts a detrimental effect on oocyte and embryo competence has no clinical validity.

摘要

目的：评价扳机日孕酮（P）水平对全胚冷冻周期活产的影响。

材料和方法：回顾性分析1034例年龄38岁的全胚冷冻的女性单囊胚移植。将患者有（n=268）或没有（n=766）胚胎植入前非整倍体基因检测（PGT-A）的患者根据扳机日P的水平进一步分为三个亚组：低 (<0.80 ng/ml), 中 (0.8–1.49 ng/ml), 高 (1.50 ng/ml)。

结果：无PGT-A组和有PGT-A组在扳机日雌二醇（E2）水平、取得卵母细胞数量和成熟卵母细胞数量随着血清P值的增加而显著增加。无PGT-A组的3个亚组的活产率（分别为51%、52.6%和51.5%; p=0.922）和有PGT-A的3个亚组的活产率（分别为55.1%, 55.1%, 和62.5%；p=0.730）相似。多因素回归分析显示, 扳机日P水平对活产无显著影响。

结论：扳机日孕酮升高（PE）对卵母细胞和胚胎产生不利影响的建议没有得到临床验证。

Keywords:

• Freeze-all
• IVF/ICSI
• trigger day progesterone

Disclosure statement

The authors report no conflicts of interest.