Vitamin D significance in pathogenesis of endometriosis

Figures & data

Table 1. Median values of 25(ОН)D concentration changes in PB based on daily intake according to GrassrootsHealth algorithm (A Public Health Promotion Organization http://www.grassrootshealth.net).

Expected level (ng/mL)	20	30	40	50	60
Real level (ng/mL)	Colecalciferol recommended daily dose (IU)
10	2000	4000	6000	10000	10000
15	1000	3000	6000	9000	10000
20		2000	5000	8000	10000
25		1000	4000	7000	10000
30			3000	6000	10000
35			1000	5000	9000
40				3000	9000

Figure 2. VDR expression in glands and stroma of eutopic endometrium – secretory phase. IHC test × 400.

Figure 3. VDR expression in endometrioid heterotopias. IHC test × 200.

Table 2. Estimation of VDR expression in endometrioid heterotopias and the endometrium of patients with GE and in the endometrium in patients from the control.

Groups	VDR expression
	Menstrual cycle phase
	Proliferative (n = 17)	Secretory (n = 30)	Pare-wise comparison*
1 Endometrioid heterotopias (n = 27)	12.88% (10.5;14.49)	10.32% (6.47;15.09)	p = .808
2 Eutopic endometrium (n = 27)	20.12% (18.1;24.24)	21.51% (17.41;24.83)	p = .314
3 Endometrium (control) (n = 20)	14.76% (11.83;23.66)	22.35% (15.82;29.45)	p = .043
Comparison between groups**	p1–3 < .001	p1–3 < .001
Pare-wise comparison***	p1–2 = .01 p1–3 = .309 p2–3 = .413	p1–2 < .001 p1–3 = .917 p2–3 = .007

*Mann-Whitney test.

**Kruskall-Wallis test.

*** DSCF test.

Figure 1. VDR expression in glands and stroma of eutopic endometrium – proliferative phase. IHC test × 400.