Abstract
Objective
To investigate whether TSH levels are associated with the pregnancy outcomes of patients in the follicular phase long-acting long protocol of IVF/ICSI.
Methods
This was a single-central, retrospective study which was conducted in the Reproductive Medicine Center, Renmin Hospital of Wuhan University from February 2019 to April 2021. A total number of 773 patients underwent the follicular phase long-acting long protocol during in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment were divided into Group A (0.5 mIU/L ≤ TSH ≤2.5 mIU/L, n = 463) and Group B (2.5 mIU/L < TSH≤ 4.5 mIU/L, n = 310) according to their serum TSH levels. The clinical data and pregnancy outcomes were compared between the two groups. The possible relationship between TSH levels and pregnancy outcomes in people who performed follicular phase long-acting long protocol was investigated.
Results
The proportion of patients with infertility due to ovulation disorders was significantly greater in Group B than in Group A (p = 0.036). The duration of Gn of Group B was significantly longer than that of Group A (p = 0.001). The Gn dose of Group B was significantly larger than that of Group A (p = 0.002). Besides, the implantation rate and miscarriage rate of embryos transferred on D3 were significantly higher in Group B than that of Group A (p = 0.033, p = 0.026 respectively).
Conclusions
The higher implantation and miscarriage rates of D3 of IVF/ICSI in the follicular phase long-acting long protocol may be related to higher serum TSH levels.
摘要
目的
探讨TSH水平与卵泡期长效长方案IVF/ICSI患者的妊娠结局是否相关。
方法
本研究为单中心、回顾性研究, 2019年2月至2021年4月在武汉大学人民医院生殖医学中心开展。将773例在体外受精 (IVF)或卵细胞浆内精子注射(ICSI)治疗中接受卵泡期长效长方案的患者根据血清TSH水平分为A组(0.5 mIU/L≤TSH≤2.5 mIU/L, n=463)和B组(2.5 mIU/L< TSH≤4.5 mIU/L, n=310)。比较两组临床资料及妊娠结局。研究实施卵泡期长效长方案患者的TSH水平与妊娠结局之间的可能关系。
结果
结果:B组因排卵障碍导致不孕的患者比例明显高于A组(p=0.036)。B组Gn持续时间明显长于A组(p=0.001)。B组Gn剂量明显高于A组(p=0.002)。此外, B组移植D3胚胎的种植率(p=0.033)和流产率(p=0.026)显著高于A组。
结论
卵泡期长效长方案IVF/ICSI D3胚胎较高的种植率和流产率可能与较高的血清TSH水平有关。
Disclosure statement
No potential conflict of interest was reported by the authors.