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Gynecological Endocrinology Volume 39, 2023 - Issue 1
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Research Article

Clinical efficacy and safety of trimonthly administration of goserelin acetate 10.8 mg in premenopausal Chinese females with symptomatic adenomyosis: a prospective cohort study

Hao Suna Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Shandong University, Jinan, China;b Medical Integration and Practice Center, Shandong University, Jinan, ChinaView further author information
,
Ming Yuana Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Shandong University, Jinan, ChinaView further author information
,
Xinyu Wanga Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Shandong University, Jinan, China;b Medical Integration and Practice Center, Shandong University, Jinan, ChinaView further author information
,
Xue Jiaoa Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Shandong University, Jinan, China;b Medical Integration and Practice Center, Shandong University, Jinan, ChinaView further author information
,
Zangyu Pana Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Shandong University, Jinan, China;b Medical Integration and Practice Center, Shandong University, Jinan, ChinaView further author information
,
Hua Lic Taian City Central Hospital, Taian, ChinaView further author information
,
Linqing Yangd Affiliated Hospital of Jining Medical University, Jining, ChinaView further author information
,
Liming Wange Affiliated Hospital of Qingdao University, Qingdao, ChinaView further author information
,
Shihong Zhangf Weihai Municipal Hospital, Weihai, ChinaView further author information
,
Qianhui Rena Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Shandong University, Jinan, China;b Medical Integration and Practice Center, Shandong University, Jinan, ChinaView further author information
,
Shumin Yana Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Shandong University, Jinan, China;b Medical Integration and Practice Center, Shandong University, Jinan, ChinaView further author information
,
Dong Lig Qilu Hospital of Shandong University, Jinan, ChinaView further author information
,
Xinmei Zhangh Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaCorrespondence[email protected]
View further author information
&
Guoyun Wanga Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Shandong University, Jinan, China;b Medical Integration and Practice Center, Shandong University, Jinan, ChinaCorrespondence[email protected]
View further author information
 show all
Article: 2160435 | Received 06 Jul 2022, Accepted 14 Dec 2022, Published online: 23 Dec 2022

Figures & data

Figure 1. Patient disposition.

Figure 1. Patient disposition.

Table 1. Baseline patient demographics and disease characteristics.

Figure 2. Dysmenorrhea scores from baseline to 12 weeks in goserelin 10.8 mg and 3.6 mg groups, 12 weeks vs baseline p < .0001.

Figure 2. Dysmenorrhea scores from baseline to 12 weeks in goserelin 10.8 mg and 3.6 mg groups, 12 weeks vs baseline p < .0001.

Figure 3. Uterine volume from baseline to 12 weeks in goserelin 10.8 mg and 3.6 mg groups, 12 weeks vs baseline p < .0001.

Figure 3. Uterine volume from baseline to 12 weeks in goserelin 10.8 mg and 3.6 mg groups, 12 weeks vs baseline p < .0001.

Figure 4. CA125 from baseline to 12 weeks in goserelin 10.8 mg and 3.6 mg groups, 12 weeks vs baseline p < .0001.

Figure 4. CA125 from baseline to 12 weeks in goserelin 10.8 mg and 3.6 mg groups, 12 weeks vs baseline p < .0001.

Figure 5. HGB from baseline to 12 weeks in goserelin 10.8 mg and 3.6 mg groups, 12 weeks vs baseline p < .0001.

Figure 5. HGB from baseline to 12 weeks in goserelin 10.8 mg and 3.6 mg groups, 12 weeks vs baseline p < .0001.

Table 2. Treatment outcomes in goserelin 10.8 mg and goserelin 3.6 mg groups.

Table 3. Incidence of adverse events occurring in goserelin 10.8 mg and 3.6 mg groups.

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