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Gynecological Endocrinology Volume 39, 2023 - Issue 1
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Research Article

Recurrent implantation failure versus recurrent implantation success: a preliminary study at proteomic level

Jing Zhaoa Reproductive Medicine Center, Xiangya Hospital, Central South University, Hunan, People’s Republic of China;b Clinical Research Center for Women’s Reproductive Health in Hunan Province, Hunan, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-3658-3274View further author information
ORCID Icon,
Jie Haoa Reproductive Medicine Center, Xiangya Hospital, Central South University, Hunan, People’s Republic of China;b Clinical Research Center for Women’s Reproductive Health in Hunan Province, Hunan, People’s Republic of ChinaView further author information
,
Bin Xua Reproductive Medicine Center, Xiangya Hospital, Central South University, Hunan, People’s Republic of China;b Clinical Research Center for Women’s Reproductive Health in Hunan Province, Hunan, People’s Republic of ChinaView further author information
&
Yanping Lia Reproductive Medicine Center, Xiangya Hospital, Central South University, Hunan, People’s Republic of China;b Clinical Research Center for Women’s Reproductive Health in Hunan Province, Hunan, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-4193-7321View further author information
ORCID Icon
Article: 2217261 | Received 05 May 2022, Accepted 18 May 2023, Published online: 30 May 2023

Figures & data

Figure 1. Volcano plot of the RIF vs. RIS.

Figure 1. Volcano plot of the RIF vs. RIS.

Figure 2. Hierarchical cluster analysis of the two groups. Samples were clustered based on the similarity of their protein expression profiles observed in log10 of the iTRAQ ratios and a dendrogram generated to indicate the relationship between the samples.

Figure 2. Hierarchical cluster analysis of the two groups. Samples were clustered based on the similarity of their protein expression profiles observed in log10 of the iTRAQ ratios and a dendrogram generated to indicate the relationship between the samples.

Figure 3. Up-regulated proteins with Go functional analysis of the RIF vs. RIS.

Figure 3. Up-regulated proteins with Go functional analysis of the RIF vs. RIS.

Figure 4. Down-regulated proteins with Go functional analysis of the RIF vs. RIS.

Figure 4. Down-regulated proteins with Go functional analysis of the RIF vs. RIS.

Figure 5. Up-regulated proteins with KEGG functional analysis of the RIF vs. RIS.

Figure 5. Up-regulated proteins with KEGG functional analysis of the RIF vs. RIS.

Figure 6. Down-regulated proteins with KEGG functional analysis of the RIF vs. RIS.

Figure 6. Down-regulated proteins with KEGG functional analysis of the RIF vs. RIS.

Figure 7. Claudin-4, p38, PRKAB, IKB-b, myosin-2, PKG2 were selected for further confirmation by Western blot to validate the data from iTRAQ analysis.

Figure 7. Claudin-4, p38, PRKAB, IKB-b, myosin-2, PKG2 were selected for further confirmation by Western blot to validate the data from iTRAQ analysis.
Supplemental material

Supplemental Material

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Data availability statement

The datasets generated during the current study are available in the repository.

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