Comparison the effects of progestin-primed ovarian stimulation (PPOS) protocol and GnRH-a long protocol in patients with normal ovarian reserve function

Figures & data

Table 1. Comparison of baseline characteristics between the two groups.

Item	PPOS protocol group	GnRH-a long protocol group	Total	p value
No. of cases	679	1334	2013
Female age (year)	30.49 ± 3.02	30.67 ± 2.45	30.61 ± 2.67	.137
Fertilization type IVF (%)	527/679(77.6)	1087/1334(81.5)	1614/2013(80.2)	.044*
Fertilization type ICSI (%)	152/679(22.4)	247/1334(18.5)	399/2013(19.8)
Infertility duration (year)	3.80 ± 2.77	3.71 ± 2.64	3.74 ± 2.68	.505
Primary infertility (%)	357/679(52.7)	741/1334(55.5)	1098/2013(54.6)	.219
secondary infertility (%)	322/679(47.3)	593/1334(44.5)	915/2013(45.4)
AMH (ng/ml)	4.52 ± 4.56	4.79 ± 2.50	4.69 ± 3.37	.091
BMI (kg/m2)	22.97 ± 3.56	23.20 ± 3.44	23.12 ± 3.48	.174
Antral follicle count	8.24 ± 4.03	8.17 ± 1.81	8.20 ± 2.77	.586
Basal serum FSH (IU/L)	7.04 ± 2.30	6.95 ± 2.06	6.98 ± 2.14	.403
Basal serum E2 (pg/mL)	72.48 ± 73.80	66.33 ± 62.92	68.41 ± 66.84	.051

Notes: *p values <0.05,

** p values <0.01.

Table 2. Comparison of controlled ovarian hyper stimulation and embryologic outcomes.

Item	PPOS protocol group	GnRH-a long protocol group	p value
No. of cases	679	1334
LH levels on trigger day (IU/L)	2.81 ± 1.07	1.01 ± 0.62	.001**
E2 levels on trigger day (pg/mL)	2135.92 ± 1387.00	2417.01 ± 1010.70	.001**
P levels on trigger day (ng/mL)	0.87 ± 0.52	0.83 ± 0.39	.103
Total Gn used dosage (IU)	1944.49 ± 533.61	2661.34 ± 987.97	.001**
Duration of Gn used (d)	10.05 ± 1.48	11.90 ± 1.85	.001**
No. of oocytes retrieved	8.03 ± 2.86	9.47 ± 2.64	.001**
2PN fertilization rate (%)	89.71	88.95	.307
Cleavage rate (%)	99.39	99.02	.029*
High-quality embryo	2.79 ± 1.60	2.82 ± 1.94	.740
Number of embryos transferred	1.69 ± 0.49	1.72 ± 0.44	.116

Notes: *p values <0.05,

** p values <0.01.

Figure 1. Distribution of reproductive outcomes of PPOS protocol group and GnRH-a long group: (A) No. of oocytes retrieved; (B) 2PN fertilization rate; (C) High-quality embryo; (D) Clinical pregnancy rate; (E) Early abortion rate; (F) Severe OHSS rate.

Table 3. Comparison of clinical outcomes (per embryo transfer cycle).

Item	PPOS protocol group	GnRH-a long protocol group	p value
No. of cases	679	1334
Clinical pregnancy rate (%)	389/679(57.3)	808/1334(60.6)	.86
Early abortion rate (%)	32/389(8.2)	71/808(8.8)	.41
Ectopic pregnancy rate (%)	2/389(0.5)	14/808(1.7)	.06
Severe OHSS rate (%)	0/679(0)	11/1334(0.82)	.001**

Notes: *p values <0.05,

** p values <0.01.