Correlation between the number of oocytes and the increase of polyspermy rate in IVF cycles

Figures & data

Table 1. Basic patient characteristics and clinical data[M(P25, P75), n(%)].

Factors	A group (n = 78)	B group (n = 118)	C group (n = 94)	D group (n = 55)	E group (n = 31)	z (χ^2)	P
Female age	32.00 (29.00,35.00)	31.00 (27.00,34.00)	30.00 (27.00, 32.00)	28.00 (26.00, 31.00)	28.00 (26.00, 30.25)	36.624	0.000*
Infertility years	3 (2,5.25)	3 (2,5)	3 (2,5.25)	3 (2,4)	3.5 (2,5.25)	0.493	0.974
Infertility type (primary/secondary)	34/44	53/65	45/49	29/26	21/10	6.363	0.174
Infertility factors(Pelvic and fallopian tube/Ovulatory dysfunction/others)	45/13/20	74/20/24	69/17/8	37/16/2	19/9/3	22.487	0.004*
Body mass index (BMI, kg/m^2)	23.15(20.98, 26.20)	22.60(20.70, 25.20)	23.95(21.50, 27.03)	22.50(21.00,25.50)	24.30(21.80,26.43)	7.627	0.106
AMH	1.14(0.70, 1.94)	1.63(1.12, 2.90)	2.38(1.62, 3.98)	5.58(2.46,10.79)	6.11(3.98,9.93)	138.391	0.000*
FSH days	9.5(8, 11)	10(9, 11)	10(9, 11)	10(9, 11)	10(9, 11)	6.564	0.161
FSH total dose (U)	2100.00(1781.25,2400.00)	2175.00(1800.00,2625.00)	1950.00(1650.00,2325.00)	1425.00(1350.00,1950.00)	1462.50(1275.00,1950.00)	50.410	0.000*
HMG days	7(4,10)	5(3, 8)	5(2, 9)	2(1,6)	1.5(0,3.5)	40.681	0.000*
HMG total dose (U)	825(506.25, 1368.75)	600(300, 975)	525(225,975)	225(75,750)	150(0,393.75)	52.374	0.000*
Gn starting dose (U)	300(225, 300)	300(225, 300)	225(150,300)	150(150,225)	150(150,225)	119.238	0.000*
LH level on trigger day (U/L)	2.05(1.58,3.51)	1.91(1.27, 3.41)	1.65(0.87,2.70)	1.72(1.00,2.94)	1.98(1.08,4.35)	11.844	0.019*
E2 level on trigger day(pg/ml)	1538.62(1101.95,2255.32)	2786.93(1994.57,3620.50)	3652.80(2957.21,4691.44)	4960,68(4023.48,6763.48)	7612.67(4907.16,10747.88)	199.046	0.000*
P level on trigger day ((ng/ml))	0.76(0.40, 1.14)	0.99(0.68, 1.46)	1.17(0.97,1.62)	1.34(1.04,1.83)	1.77(1.23,2.45)	74.597	0.000*
Number of oocytes	4(3,5)	8(7,9)	12(11,14)	17(16,19)	26(24,30)	353.863	0.000*
Proportion of immature oocytes, n (%)	0.00(0.00,33.33)	11.11(0.00,25.00)	9.09(6.67,25.00)	12.50(0.00,22.22)	12.50(4.41,21.99)	2.827	0.587
Level of polyspermy rate [Normal level(polyspermy rate<6%)/High level(polyspermy rate ≥ 6%)]	52/26	58/60	29/65	22/33	9/22	26.940	0.000*

注:*p < .05.

Table 2. Logistic regression analysis of factors related to polyspermy rate of IVF cycles.

Factors	Univariate regression			Multiple regression
	P value	OR	95%CI	P value	OR	95%CI
Female age	0.682	0.991	0.947-1.037
Infertility years	0.783	1.010	0.942-1.083
Infertility type (secondary vs. primary)	0.574	1.124	0.748-1.687
Infertility factors	0.036*			0.197
Pelvic and fallopian tube factors		1.000			1.000
Ovulatory dysfunction	0.283	0.752	0.447-1.265	0.232	0.701	0.391-1.255
Others	0.012*	0.470	0.261-0.845	0.123	0.600	0.313-1.149
Body mass index (BMI, kg/m^2)	0.767	1.008	0.955-1.065
AMH	0.028*	1.066	1.007-1.128	0.800	1.011	0.930-1.098
FSH days	0.034*	1.133	1.010-1.271	0.278	1.074	0.944-1.223
FSH total dose (U)	0.395	1.000	0.999-1.000
HMG days	0.709	0.990	0.939-1.044
HMG total dose (U)	0.579	1.000	1.000-1.000
Gn starting dose (U)	0.040*	0.997	0.994-1.000	0.698	1.001	0.996-1.005
LH level on trigger day (U/L)	0.117	0.921	0.831-1.021
E2 level on trigger day(pg/ml)	0.000*	1.000	1.000-1.000	0.604	1.000	1.000-1.000
P level on trigger day ((ng/ml))	0.003*	1.604	1.172-2.196	0.328	1.218	0.820-1.807
Proportion of immature oocytes	0.000*	0.036	0.009-0.154	0.000*	0.026	0.005-0.131
Number of oocytes	0.000*			0.015*
A group		1.000			1.000
B group	0.016*	2.069	1.143-3.744	0.085	1.763	0.924-3.364
C group	0.000*	4.483	2.357-8.525	0.001*	3.804	1.746-8.285
D group	0.003*	3.000	1.466-6.139	0.158	2.021	0.761-5.368
E group	0.001*	4.889	1.973-12.112	0.068	3.208	0.918-11.210

注:*p < .05.