Phyto-progestins for the treatment of abnormal uterine bleeding without organic cause in women at high risk for breast cancer and breast cancer survivors: a prospective, pilot study

Figures & data

Table 1. Baseline features of the subjects included in the study. Values are expressed in mean ± standard deviation (SD).

	Subjects (n = 15)
Age (years)	42.4 ± 6.2 (29–51)
Weight (Kg)	67.5 ± 9.5 (55–87)
Previous breast cancer (%)	4/15 (26.7%)
Genetic mutation
BRCA 1	5/15 (33.3%)
BRCA 2	7/15 (46.7%)
Other	3/15 (20.0%)

Table 2. Baseline and after treatment characteristics of bleeding and pain characteristics during Menstruation.

	Baseline cycle (n = 15)	Mean of 3 cycles of treatment (n = 15)	p-value
Cycle length (days)	Irregular	27.1 ± 3.2	/
Menstrual flow length (days)	4.86 ± 0.30	5.14 ± 0.34	0.40
Menstrual flow intensity (points per day of flow)	1.91 ± 0.14	1.60 ± 0.10	0.02
Menstrual pain intensity (points per day of flow)	1.81 ± 0.19	1.30 ± 0.12	0.02
Number of painkillers taken	1.1 ± 0.36	0.59 ± 0.23	0.07

Table 3. Baseline and after treatment characteristics of Short Form 36 questionnaire (with specific domains), of Green Climacteric Scale (with specific domains) and the Psychological General Well-Being Index (with specific domains).

Questionnaires	Pre treatment	After treatment	p-value
Short form 36 (n = 15)	76.2 ± 3.9	75.4 ± 3.8	0.66
Pain	73.8 ± 6.2	72.8 ± 5.2	0.87
Physical function	92.7 ± 2.2	91.7 ± 2.7	0.49
Physical problem	88.3 ± 8.0	85.0 ± 8.0	0.16
Social activities	72.5 ± 7.1	74.2 ± 6.0	0.74
Mental health	66.8 ± 5.2	65.3 ± 5.9	0.73
Emotional problems	80.0 ± 6.5	81.1 ± 8.4	0.91
Energy	59.0 ± 5.7	60.3 ± 5.1	0.36
General health	65.0 ± 5.3	61.7 ± 5.3	0.51
Green Climacteric Scale (n = 10)	13.8 ± 2.3	13.8 ± 3.4	0.99
Anxiety	3.6 ± 0.9	3.3 ± 0.9	0.73
Depression	4.4 ± 1.9	3.7 ± 1.1	0.45
Somatic	4.2 ± 0.6	4.3 ± 3.7	0.91
Vasomotor	0.4 ± 0.2	0.7 ± 0.3	0.17
Sexual dysfunction	1.2 ± 0.8	1.3 ± 0.3	0.68
The Psychological General Well-Being Index (n = 15)	57.3 ± 1.2	58.4 ± 0.9	0.28
Anxiety	14.8 ± 0.8	16.1 ± 3.9	0.1
Depression	10.3 ± 0.2	10.1 ± 0.4	0.36
Well-being	10.3 ± 0.2	10.5 ± 0.4	0.70
Self-control	5.2 ± 0.4	5.4 ± 0.4	0.81
General health	8.3 ± 0.5	8.5 ± 0.3	0.77
Vitality	8.0 ± 0.4	7.9 ± 0.5	0.66

Data availability statement

The data that support the findings of this study are available from the corresponding author, [GG], upon reasonable request.