Trimester-specific reference intervals of serum homocysteine levels for pregnant women: a longitudinal study in China

Figures & data

Figure 1. Participant recruitment. TC: total cholesterol and triglyceride TG: triglyceride.

Table 1. Baseline Characteristic of the participants.

	Total	Nonpregnant	Pregnant
			First trimester	Second trimester	Third trimester
N	476	120	118	120	118
Age(years)	31.0 ± 4.1	31.9 ± 4.7	31.1 ± 4.3	31.3 ± 4.0	30.4 ± 3.6
SBP(mm Hg)	113.4 ± 11.5	116.6 ± 10.8	112.6 ± 10.1	111.1 ± 10.5	113.1 ± 13.6
DBP(mm Hg)	72.9 ± 8.7	74.9 ± 8.3	72.7 ± 8.8	71.7 ± 9.0	72.5 ± 8.4
TC(mmol/L)	4.5 ± 0.8	4.2 ± 0.6	4.1 ± 0.6	4.7 ± 0.7	5.0 ± 0.7
TG(mmol/L)	1.4 ± 0.5	0.9 ± 0.4	1.2 ± 0.4	1.5 ± 0.4	1.9 ± 0.3

Values are mean ± SD or median (range) unless otherwise indicated. Abbreviations: SBP, systolic blood pressure; DBP, diastolic blood pressure; TC, total cholesterol; TG, triglycerides.

Table 2. The RIs of serum Hcy for healthy nonpregnant women and healthy pregnant women (μmol/L).

Group	N	Median	2.5th percentile and 90% CI	97.5th percentile and 90% CI	Reference intervals
Nonpregnant	120	8.53	5.59 (5.26–5.91)	13.1 (12.61–19.56)	5.59–13.10
First trimester	118	6.49	4.35 (3.88–4.71)	10.16 (9.12–11.85)	4.35–10.16
Second trimester*	120	5.84	3.38 (2.91–4.20)	8.6 (7.41–15.56)	3.38–8.60
Third trimester*	118	6.56	3.75 (3.70–4.75)	11.17 (10.00–12.70)	3.75–11.17

*Comparison of serum HCY: there were statistically difference for serum Hcy levels between pregnant women in the first, the second, and the third trimesters of gestation (p < 0.05).

Figure 2. The change of serum Hcy levels (median) in healthy nonpregnant and pregnant woman in different trimesters.

Data availability statement

The data are available from the corresponding author on reasonable request.