Prevalence of diminished ovarian reserve in Chinese women with follicular cysts and menstrual disorders

Figures & data

Table 1. The baseline data of patients with follicular cysts and menstrual disorders (mean ± SD or Median (P25, P75)).

Variables	Mean ± SD or Median (P25, P75)	Min-Max
Age, years	39.19 ± 6.61	24-53
BMI, kg/m^2	23.28 ± 2.65	18.72-31.80
FSH, mIU/ml	5.52 (3.11, 7.57)	0.33-79.79
LH, mIU/ml	3.8 (1.95, 6.76)	0.95-56.17
FSH/LH ratio	1.29 (0.64, 2.48)	0.08-6.13
E2, pg/ml	126.31 (64.51, 240.46)	50.52-841.01
Po, ng/ml	0.5 (0.38, 0.69)	0.03-1.61
PRL, ng/ml	9.10 (6.60, 13.68)	2.33-28.70
Testosterone, nmol/l	0.73 ± 0.29	0.01-1.62
AMH, ng/ml	0.25 (0.13, 0.70)	0.03-11.09
Diameter of ovarian cyst, cm	2.70 (2.50, 3.10)	2.0-4.8
Endometrial thickness, cm	0.83 (0.65, 1.10)	0.3-2.0

Min: minimum; Max: maximum; BMI: body mass index; FSH: follicle stimulating hormone; LH: luteinizing hormone; E2: estradiol; Po: progesterone; PRL: prolactin; AMH: anti-Müllerian hormone.

Table 2. Comparison of different parameters between different age groups. (mean ± SD or Median (P25, P75)).

	Group-1 (21 ∼ 30 years) (n = 16)	Group-2 (31-40 years) (n = 38)	Group-3 (>40 years) (n = 63)	P
BMI, kg/m^2	23.04 ± 3.12	23.57 ± 2.41	23.16 ± 2.68	0.704
FSH, mIU/ml	5.61 (2.97, 7.32)	4.39 (1.97, 6.50)	6.00 (3.37, 9.71)	0.068
LH, mIU/ml	3.41 (1.89, 8.57)	2.95 (1.87, 6.14)	4.79 (2.28, 7.59)	0.542
FSH/LH ratio	1.28 (0.58, 2.48)	1.21 (0.51, 1.96)	1.35 (0.71, 2.58)	0.328
E2, pg/ml	73.09 (57.76, 187.21)	117.26 (68.54, 233.35)	145.13 (62.40, 257.21)	0.158
Po, ng/ml	0.56 (0.40, 0.65)	0.50 (0.35, 0.74)	0.49 (0.40, 0.63)	0.763
PRL, ng/ml	10.43 (8.67, 15.56)	10.39 (6.63, 15.66)	8.53 (6.44, 12.80)	0.155
Testosterone, nmol/l	0.83 ± 0.30	0.83 ± 0.33	0.65 ± 0.24^a^,b	0.006*
AMH (ng/ml)	1.05 (0.88, 1.70)	0.35 (0.22, 0.93)^a	0.15 (0.11, 0.26)^a^,b	<0.001*
Diameter of ovarian cyst, cm	2.97 ± 0.76	2.88 ± 0.58	2.81 ± 0.54	0.571
Endometrial thickness, cm	0.88 ± 0.39	0.83 ± 0.29	0.92 ± 0.33	0.389

BMI: body mass index; FSH: follicle stimulating hormone; LH: luteinizing hormone; E2: estradiol; Po: progesterone; PRL: prolactin; AMH: anti-Müllerian hormone.

^a p < 0.05 compared with group-1; ^bp < 0.05 compared with group-2.

Table 3. Correlation between AMH and other indices in participants.

Variables	Group-1 (21 ∼ 30 years) (n = 16)	Group-2 (31-40 years) (n = 38)	Group-3 (>40 years) (n = 63)	All the participants (n = 117)
Age, years	−0.179	−0.386*	−0.459**	−0.672**
BMI, kg/m^2	−0.099	−0.189	0.283*	0.069
FSH, mIU/ml	−0.162	0.033	−0.052	−0.104
LH, mIU/ml	0.540*	0.271	−0.236	−0.040
FSH/LH ratio	−0.785**	−0.226	0.200	−0.053
E2, pg/ml	0.006	−0.327*	−0.201	−0.241**
Po, ng/ml	0.631**	0.066	−0.185	0.001
PRL, ng/ml	0.211	−0.295	−0.186	−0.049
Testosterone, nmol/l	0.957**	0.252	0.042	0.248*
Diameter of ovarian cyst, cm	0.550*	0.153	−0.059	0.078
Endometrial thickness, cm	0.230	−0.066	0.124	−0.023

* p < 0.05, **p < 0.01.

BMI: body mass index; FSH: follicle stimulating hormone; LH: luteinizing hormone; E2: estradiol; Po: progesterone; PRL: prolactin; AMH: anti-Müllerian hormone.

Data availability statement

The authors confirm that the data supporting the findings of this study are available within the article.