Correlation between chronic low-grade inflammation and glucose and lipid metabolism indicators in polycystic ovary syndrome

Figures & data

Table 1. Basic data of the control and PCOS groups.

Variables	PCOS group (n = 110)	Control group (n = 126)	P
Age (years)	28.55 ± 4.65	29.71 ± 4.41	0.742
Weight (kg)	56.89 ± 6.30	54.15±±7.10	0.002
BMI (kg/m^2)	23.64 ± 3.31	21.81 ± 3.38	<0.001

Table 2. Comparison of inflammatory markers between the control and PCOS groups.

Variables	PCOS group (n = 110)	Control group (n = 126)	P
WBC	6.57 ± 1.67	5.65 ± 1.10	<0.001
PLT	261.43 ± 70.31	234.21 ± 61.32	0.213
Neutrophils	3.88 ± 1.23	3.18 ± 0.85	0.000
Lymphocyte	2.12 ± 0.58	1.95 ± 0.41	0.006
Monocyte	0.40 ± 0.13	0.36 ± 0.09	0.001
NLR	1.92 ± 0.72	1.69 ± 0.51	0.003
PLR	127.67 ± 36.55	123.02 ± 32.46	0.286
MLR	0.20 ± 0.06	0.19 ± 0.05	0.123

WBC, white blood cell count; PLT, platelets; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio; MLR, monocyte-to-lymphocyte ratio.

Table 3. Comparison of hormone and blood lipid indicators between the control and PCOS groups.

Variables	PCOS group	Control group	P
E	67.08 (43.14, 75.56)	58.26(39.31, 75.17)	0.094
LH	10.27(5.09, 15.28)	8.06 (3.76, 8.46)	<0.001
FSH	5.95(4.68, 7.02)	6.78 (5.36, 7.78)	0.002
PRL	13.69(7.92, 12.44)	12.31 (5.36, 7.78)	0.169
P	1.16(0.40, 0.73)	1.53 (0.46, 0.67)	0.609
TSTO	33.07(25.16, 40.86)	25.26 (19.99, 29.85)	0.000
TC	4.94 ± 1.11	4.94 ± 0.75	0.030
TG	1.69 ± 1.52	0.98 ± 0.43	<0.001
HDL	1.25 ± 0.33	1.51 ± 0.32	0.646
LDL	2.87 ± 0.84	2.66 ± 0.65	0.166

E, Estradiol; FSH, follicle stimulating hormone; LH, luteinizing hormone; P, progesterone; TSTO, testosterone; TC, total cholesterol; TG, triglyceride; LDL, low-density lipoprotein; HDL, high-density lipoprotein.

Table 4. Comparison of inflammatory markers between the control and PCOS groups with BMI ≥ 24.

Variables	PCOS group (n = 45)	Control group (n = 34)	P
WBC	6.49 ± 1.52	5.78 ± 1.23	0.029
PLT	249.07 ± 67.88	234.06 ± 58.33	0.411
Neutrophils	3.95 ± 1.25	3.37 ± 0.98	0.027
Lymphocyte	2.01 ± 0.56	1.91 ± 0.39	0.359
Monocyte	0.39 ± 0.12	0.37 ± 0.10	0.227
NLR	2.09 ± 0.86	1.81 ± 0.56	0.101
PLR	128.82 ± 39.36	127.12 ± 31.26	0.837
MLR	0.20 ± 0.06	0.19 ± 0.06	0.610

WBC, white blood cell count; PLT, platelets; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio; MLR, monocyte-to-lymphocyte ratio.

Table 5. Comparison of inflammatory markers between the control and PCOS groups with BMI < 24.

Variables	PCOS group (n = 65)	Control group (n = 92)	P
WBC	6.63 ± 1.78	5.61 ± 1.06	<0.001
PLT	269.98 ± 71.21	233.15 ± 62.67	0.001
Neutrophils	3.84 ± 1.24	3.12 ± 0.79	<0.001
Lymphocyte	2.20 ± 0.58	1.96 ± 0.42	0.003
Monocyte	0.41 ± 0.13	0.36 ± 0.09	0.020
NLR	1.79 ± 0.58	1.64 ± 0.48	0.078
PLR	126.87 ± 34.77	121.51 ± 32.93	0.328
MLR	0.19 ± 0.06	0.19 ± 0.05	0.985

WBC, white blood cell count; PLT, platelets; NLR, neutrophil-to-lymphocyte ratio; PLR, platelet-to-lymphocyte ratio; MLR, monocyte-to-lymphocyte ratio.

Table 6. Independent risk factors for PCOS among inflammatory factors, blood lipids and hormones.

Variables	OR	95%CI	P
FSH	1.258	1.039–1.522	0.019
TSTO	0.892	0.853–0.932	<0.001
TG	0.265	0.109–0.643	0.009

FSH, follicle stimulating hormone; TSTO, testosterone; TG, triglyceride.

Data availability statement

All relevant data are included in the paper. The datasets used and/or analyzed during the current study available from the corresponding author upon reasonable request.