Effects of growth hormone therapy on the onset and progression of pubertal development in girls with idiopathic short stature

Figures & data

Figure 1. Screening conditions for 60 cases in the growth hormone therapy group.

Figure 2. (A) Comparison of age at puberty; (B) comparison of age at menarche; (C) comparison of the period of sexual maturation; (D) comparison of height at puberty; (E) comparison of height at menarche; (F) comparison of height growth from puberty to menarche.

Table 1. Comparison of developmental indicators between the treatment group and the control group.

	GH treatment (n = 60)	Controls (n = 66)	t value	P
Age at puberty (y)	9.89 ± 1.10	9.58 ± 1.07	1.532	0.128
Height at puberty (cm)*	131.63 ± 6.26	127.08 ± 6.18	4.426	<0.001
Height SDS at puberty	−1.28 ± 0.59	−1.84 ± 0.42	6.16	<0.001
Bone age at puberty (y)*	8.81 ± 1.32	9.76 ± 1.04	−4.344	<0.001
Age at menarche (y)*	12.71 ± 0.93	11.91 ± 0.88	4.804	<0.001
Height at menarche (cm)	152.29 ± 4.49	146.26 ± 5.51	6.639	<0.001
Height SDS at menarche	−0.31 ± 0.62	−0.72 ± 0.70	3.46	0.001
Bone age at menarche (y)	12.63 ± 0.61	12.68 ± 0.49	−0.435	0.665
The period of sexual maturation (y)*	2.82 ± 0.87	2.32 ± 0.73	3.345	0.001
Height growth from puberty to menarche (cm)*	20.31 ± 6.27	19.18 ± 3.31	1.274	0.218
Target height (cm)	154.64 ± 3.71	156.60 ± 3.29	−3.04	0.004

*p < 0.05.

Figure 3. (A) The correlation between GH usage time and age at onset of development; (B) the correlation between GH usage time and age at menarche.

Table 2. Correlation analysis of GH usage duration and development indicators in the treatment group.

	The duration of growth hormone therapy (y)
	r	P
Age at puberty (y)*	−0.312	0.016
Height at puberty (cm)	−0.135	0.31
Bone age at puberty (y)	−0.108	0.417
Age at menarche (y)*	−0.278	0.033
Height at menarche (cm)	0.038	0.774
Bone age at menarche (y)	0.001	0.994

*p < 0.05.

Data availability statement

The datasets generated and/or analyzed during the current study are not publicly available due to confidentiality agreements and the need to adhere to ethical guidelines but are available from the corresponding author upon reasonable request.