Effect of body mass index on progesterone level on trigger day in gonadotropin-releasing hormone antagonist cycles

Figures & data

Table 1. Basic patient characteristics and clinical data [M(P25,P75), n(%)].

Factors	Normal weight group(n = 230)	Overweight group (n = 122)	Obesity group (n = 60)	z(χ^2)	p
Female age	30(27,33)	30(27,34)	29(26.25,31.75)	4.479	.106
Infertility years	3(2,5)	3(2,5)	3(2,5)	1.861	.394
Infertility type (primary/secondary)	106/124	62/60	32/28	1.360	.507
Infertility factors (Pelvic and fallopian tube/Ovulatory Disorders /Diminished ovarian reserve/Uterine factors/Others)	138/39/18/8/27	81/25/3^🔺 /1/12	38/18^🔺 /3/0/1^🔺 ^#	17.744	.023*
Body mass index(BMI, kg/m^2)	21.50(20.70,22.70)	25.85(24.68,26.73)^🔺	29.50(28.60,31.28)^🔺 ^#	327.670	.000*
Basal FSH(U/L)	7.07(5.73,8.45)	6.14(5.29,7.47)^🔺	6.08(5.15,7.97)^🔺	16.475	.000*
Basal LH(U/L)	4.03(3.18,5.37)	3.60(2.48,4.86)^🔺	2.72(1.99,4.36)^🔺 ^#	18.427	.000*
Basal E2(pg/ml)	43.83(35.64,55.90)	46.18(36.51,52.89)	39.58(32.25,49.94)	4.599	.100
Basal P(ng/ml)	0.63(0.48,0.81)	0.66(0.49,0.82)	0.61(0.42,0.89)	1.123	.570
FSH days	10(9, 11)	10(9, 11)	10.50(9, 11.75)	9.247	.010*
FSH total dose(U)	1875(1425, 2250)	1950(1500, 2343.75)	2137.50(1800, 2700.00)^🔺^#	11.918	.003*
HMG days	4(1,7)	5(2,8)^🔺	7(2.25,10)^🔺	14.353	.001*
HMG total dose(U)	450(150,750)	600(206.25,975)^🔺 🔺	825(300,1275)^🔺	14.321	.001*
Gn starting dose(U)	225(150,300)	225(150,300)	262.5(225,300)	5.816	.055
LH level on trigger day(U/L)	1.90(1.14,3.32)	2.10(1.20,3.27)	1.84(1.30,2.77)	0.926	.629
E2 level on trigger day(pg/mL)	3081.55(2269.18,4974.05)	3373.45(1890.45,4665.70)	3256.39(1920.04,4400.59)	0.603	.740
P level on trigger day((ng/mL))	1.22(0.83,1.65)	1.01(0.64,1.48)^🔺	1.02(0.75,1.28)^🔺	12.458	.002*

Compared among the three groups.

* p < .05; compared with normal weight group.

^🔺 p < .05; compared with overweight group.

^# p < .05.

Table 2. Logistic regression analysis of factors related to P level on trigger day.

Factors	Univariate regression			Multiple regression
	p Value	OR	95%CI	p Value	OR	95%CI
Female age	.334	0.976	0.929–1.025
Infertility years	.103	0.935	0.863–1.014
Infertility type (secondary vs. primary)	.951	1.013	0.661–1.554
Infertility factors	.451			.682
Pelvic and fallopian tube factors		1.000			1.000
Ovulatory Disorders	.501	0.826	0.474–1.440	.208	0.645	0.326–1.276
Diminished ovarian reserve	.073	0.322	0.093–1.111	.558	0.673	0.178–2.535
Uterine factors	.588	0.644	0.131–3.168	.431	0.503	0.091–2.781
Others	.925	0.966	0.467–1.996	.989	0.994	0.441–2.242
Groups	.003			.000*
Normal weight group		1.000			1.000
Overweight group	.051	0.611	0.373–1.001	.005*	0.434	0.242–0.779
Obesity group	.002	0.288	0.131–0.637	.001*	0.199	0.079–0.505
Basal FSH (U/L)	.004	0.848	0.758–0.949	.194	0.908	0.786–1.050
Basal LH (U/L)	.104	1.085	0.984–1.196	.942	1.005	0.878–1.150
Basal E2 (pg/mL)	.670	0.998	0.987–1.009
Basal P (ng/mL)	.008	3.002	1.328–6.876	.013*	3.475	1.301–9.283
FSH days	.013	1.170	1.034–1.323	.427	1.134	0.831–1.549
FSH total dose (U)	.110	1.000	0.999–1.000	.958	1.000	0.999–1.001
HMG days	.568	0.984	0.930–1.041	.452	1.074	0.892–1.293
HMG total dose (U)	.577	1.000	0.999–1.000	.775	1.000	0.998–1.001
Gn starting dose (U)	.003	0.995	0.992–0.998	.587	1.002	0.994–1.011
LH level on trigger day (U/L)	.694	0.979	0.882–1.087
E2 level on trigger day(pg/mL)	.000	1.000	1.000–1.001	.000*	1.000	1.000–1.001

Ovulatory Disorders are those in which oocytes fail to mature or discharge properly; FSH ≥ 10IU/L is used as the diagnostic criteria for diminished ovarian reserve.

* p < .05.

Data availability statement

The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.