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Original Articles

Arachidonic acid-induced platelet aggregation and acetylsalicylic acid treatment during pregnancy in women with recurrent miscarriage, a post hoc study

ORCID Icon, , &
Pages 278-284 | Received 05 Sep 2020, Accepted 19 Jan 2021, Published online: 01 Mar 2021

Figures & data

Figure 1. Flow chart of potentially eligible and ultimately included women. Normal AA-induced platelet aggregation: ASPI test ≥ 30 U.

Figure 1. Flow chart of potentially eligible and ultimately included women. Normal AA-induced platelet aggregation: ASPI test ≥ 30 U.

Table I. Demographics, non-pregnant platelet aggregation after activation by arachidonic acid and platelet count at baseline (non-pregnant state)

Table II. Absolute changes in arachidonic acid-induced platelet aggregation (ASPI test) in women with unexplained recurrent miscarriage and healthy women with normal pregnancy. Comparisons of the non-pregnant state and during pregnancy, within and between the study groups, treated with ASA or placebo or no treatment

Figure 2. AA-induced platelet aggregation in women with unexplained recurrent miscarriage and in healthy women with normal obstetric history and normal pregnancies and deliveries at term. Participants were given ASA or placebo. No treatment was given to healthy controls. All women had normal AA-induced platelet aggregation in the non-pregnant state and had available results from all testing occasions. Boxplots show mean, median, 25th and 75th percentiles, min and max. O denotes outliers.

Figure 2. AA-induced platelet aggregation in women with unexplained recurrent miscarriage and in healthy women with normal obstetric history and normal pregnancies and deliveries at term. Participants were given ASA or placebo. No treatment was given to healthy controls. All women had normal AA-induced platelet aggregation in the non-pregnant state and had available results from all testing occasions. Boxplots show mean, median, 25th and 75th percentiles, min and max. O denotes outliers.

Figure 3. Proportion with different degrees of decrease in AA-induced platelet aggregation, according to gw, in women with unexplained recurrent miscarriage, treated with ASA or placebo, and in healthy women with normal pregnancy AA: arachidonic acid, ASA: acetylsalicylic acid, gw: gestational week.

Figure 3. Proportion with different degrees of decrease in AA-induced platelet aggregation, according to gw, in women with unexplained recurrent miscarriage, treated with ASA or placebo, and in healthy women with normal pregnancy AA: arachidonic acid, ASA: acetylsalicylic acid, gw: gestational week.