Antioxidant and immunomodulatory effects of a α-glucan from fruit body of maitake (Grifola frondosa)

Figures & data

Figure 1. Effect of MT-α-glucan on body weight of D-gal-induced ageing mice.

Table 1. Effect of MT-α-glucan on the behaviour of D-gal-induced ageing mice.

Group	Dose (mg kg^−1)	Fall number	Fall rate (%)	SDL (s)	NOE
Normal	—	1^**	10	87.11±15.19^**	0.95±0.50^**
D-gal	+	8	80	49.35±13.20	2.13±0.77
MT-α-glucan	150	3^**	30	70.52±15.61^**	0.92±0.55^**
	450	1^**	10	79.47±13.45^**	0.90±0.49^**
VE	50	3^**	30	71.69±14.24^**	0.97±0.62^**

Note: Data are the mean ± s.d., n=10. In each vertical column, *P < 0.05 and **P < 0.01, compared with the D-gal group (analysis of variance followed by the Student–Newman–Keuls test).

Table 2. Effect of MT-α-glucan on hepatic SOD, GSH_PX activity and MDA GSH content of D-gal-induced ageing mice.

Group	Dose (mg kg^−1)	SOD [U (mg protein)^−1]	MDA [nmol (mg protein)^−1]	GSHPX [U (mg protein)^−1)]	GSH [mg (g protein)^−1]
Normal	—	82.37±3.79^**	0.56±0.20^**	231.27±15.52^**	65.36±6.37^**
D-gal	—	56.83±3.02	1.89±0.43	169.33±16.71	40.94±5.80
MT-α-glucan	150	66.30±2.74^**	0.84±0.19^**	181.28±14.08	51.09±7.33^**
	450	72.94±4.05^**	0.75±0.23^**	190.73±15.09^*	56.42±6.15^**
VE	50	69.61±3.66^**	0.69±0.26^**	196.44±16.03^**	59.53±6.93^**

Note: Data are the mean ± s.d., n=10. In each vertical column, *P < 0.05 and **P < 0.01, compared with the D-gal group (analysis of variance followed by the Student–Newman–Keuls test).

Figure 2. Effect of MT-α-glucan on spleen proliferative response and IL-2 production of D-gal-induced ageing mice. Data are the mean ± s.d., n=10. In each vertical column, *P < 0.05 and **P < 0.01, compared with the D-gal group (analysis of variance followed by the Student–Newman–Keuls test).

Table 3. Effect of MT-α-glucan on thymus index and NO production by macrophages in D-gal-induced-ageing mice.

Group	Dose (mg kg^−1)	Thymus index mg g^−1 BW	NO (µmol/L)	NOS (U/mL)	iNOS (U/mL)
Normal	—	1.22±0.29**	286.33±67.27**	5.47±0.24**	3.16±0.22**
D-gal	—	0.79±0.26	504.13±70.91	8.51±0.62	4.37±0.30
MT-α-glucan	150	1.03±0.18*	358.06±65.70**	6.49±0.30**	3.65±0.34**
	450	1.12±0.23*	305.34±69.14**	6.71±0.55**	3.40±0.22**
VE	50	1.00±0.19	493.48±72.32	7.82±0.90	3.95±0.47*

Note: Data are the mean ± s.d., n=10. In each vertical column, *P < 0.05 and **P < 0.01, compared with the D-gal group (analysis of variance followed by the Student–Newman–Keuls test).

Figure 3. Effect of MT-α-glucan on macrophage proliferative response and IL-1 production of D-gal-induced-ageing mice. Data are the mean ± s.d., n=10. In each vertical column, *P < 0.05 and **P < 0.01, compared with the D-gal group (analysis of variance followed by the Student–Newman–Keuls test).