Alleviation of cyclophosphamide-induced immunosuppression in mice by naturally acetylated hemicellulose from bamboo shavings

Figures & data

Table 1. Effect of BSH on serum hemolysin formation and NK cell activity in mice.

Group^a	Serum hemolysin (HC50)	Carbon Clearance Phagocytic Index	NK cell activity (%)
NC	255.50 ± 28.54	5.21 ± 0.39	29.94 ± 5.04
CPA	47.23 ± 10.74**	4.41 ± 0.40**	22.66 ± 4.62*
CPA + LNT (50)	71.91 ± 16.79**^#	5.24 ± 0.49^##	29.98 ± 5.41^#
CPA + BSH (50)	63.80 ± 17.34**	4.61 ± 0.25*	28.50 ± 5.40
CPA + BSH (100)	73.68 ± 21.62**^#	5.18 ± 0.44^##	29.73 ± 5.13^#
CPA + BSH (200)	82.69 ± 21.88**^##	5.10 ± 0.67^#	30.64 ± 5.55^#
BSH (200)	296.54 ± 39.25*	5.43 ± 0.52	33.25 ± 5.34

^aNC, normal control; CPA, cyclophosphamide; BSH, bamboo-shavings hemicellulose; LNT, lentinan (positive control); HC₅₀, half value of hemolysis [serum antibody level in response to sheep red blood cells (SRBCs)]. Values are expressed as mean ± SD of eight mice.

*p < .05.

**p < .01 vs. NC group.

^#p < .05.

^##p < .01 vs. CPA group.

Figure 1. Effect of BSH on splenocyte proliferation in mice. NC, normal control; CPA, cyclophosphamide; BSH, bamboo-shavings hemicellulose; LNT, lentinan (positive control). Values are expressed as mean ± SD of eight mice. *p < .05 and **p < .01 vs. NC group, ^#p < .05 and ^##p < .01 vs. CPA group.

Figure 2. Effect of BSH on cytokine production from splenocytes in mice. (a) IL-2; (b) IL-4; (c) IL-10; (d) IL-12, (e) TNF-α; (f) IFN-γ. NC, normal control; CPA, cyclophosphamide; BSH, bamboo-shavings hemicellulose; LNT, lentinan (positive control). Values are expressed as mean ± SD of eight mice. *p < .05 and **p < .01 vs. NC group, ^#p < .05 and ^##p < .01 vs. CPA group.

Figure 3. Effect of BSH on T-bet and GATA-3 mRNA expression in splenocytes of mice. NC, normal control; CPA, cyclophosphamide; BSH, bamboo-shavings hemicellulose; LNT, lentinan (positive control). Values are expressed as mean ± SD of eight mice. *p < .05 and **p < .01 vs. NC group, ^#p < .05 and ^##p < .01 vs. CPA group.