Impact of lipoatrophy on quality of life in HIV patients receiving anti-retroviral therapy1

1. Presented at the 9th International Workshop on Adverse Drug Reactions and Lipodystrophy in HIV, Sydney, Australia, July 18–20, 2007

Figures & data

Table 1. Comparison of SF-8 Norms for the general US population with those for HIV-infected individuals.

	Norm for US general population (n = 7472)*		Scores for HIV-infected individuals (n = 871)**
SF-8 item	Mean	SD***	Mean
Physical functioning (PF)	48.27	7.75	43.87
Role physical (RP)	48.59	7.83	43.48
Bodily pain (BP)	50.00	8.58	45.87
General health (GH)	49.44	7.45	46.75
Vitality (VT)	50.06	7.82	46.65
Social function (SF)	48.54	8.21	42.81
Role emotion (RE)	47.04	7.18	41.90
Mental health (MH)	48.97	8.77	41.40
Notes: *Data “Norm for US general population” are from the MOS scoring manual.
**Data for the HIV-infected individuals (with no lipoatrophy reported) are from CHS survey. N for the 8 items ranged from 859–871.
***Using this standard deviation (SD), the clinically meaningful difference between the groups (Cohen's effect size) for each item ranges from medium to large.

Table 2. Data collected during the period from 11/03 to 01/06.

Source: Wave and site		Distributed/ attempted	Completed n (%)
Wave 2	Community Center/clinic	NA	1024 (NA)
Wave 3	Community Center/clinic	NA	313 (NA)
Wave 3	In-person interviews	261	237 (91)
Wave 3	Internet interviews	550	451 (82)
	Total	NA	2025

Table 3. Demographic characteristics of the study cohort of HIV-infected individuals.

		Lipoatrophy
Lipoatrophy and demographic variables	Overall	Yes	No	p-value*
Self-report of lipoatrophy (n)	1124	212	912
Age group		n = 212	n = 912	ns
20–29	4.9	7.6	4.3
30–39	24.3	22.2	24.8
40–49	43.6	43.9	43.5
50–59	21.6	21.2	21.7
60–69	4.3	3.3	4.5
70 +	1.3	1.9	1.2
Ethinicity		n = 204	n = 891	<0.0001
African American	28.1	16.7	30.8
American Indian	2.9	8.8	1.6
Asian	6.4	6.9	6.3
Hispanic	37.6	36.3	37.9
White	24.9	31.4	23.5
Sex		n = 209	n = 900	ns
Female	21.3	19.6	21.7
Male	78.7	80.4	78.3
Employment status		n = 199	n = 839	ns
Full time	26.7	26.1	26.8
Part time	9.8	8.5	10.1
Homemaker	2.7	5.5	2
Retired	4.9	3.5	5.2
Unemployed	10.8	8.5	11.3
Disabled	44.9	47.7	44.2
No answer	0.2	0	0.2
Notes: *p-value based on Pearson Chi-square test for each demographic variable.

Table 4. Effect of lipoatrophy on SF-8. Summary scores and item scores.

	Lipoatrophy
SF-8 variables	n	Yes	n	no	p-value	Diff	Total pop. SD	CMD*
Physical component summary (PCS)	190	40.58	832	45.17	<0.0001	4.585	10.626	0.431
Mental component summary (MCS)	190	37.83	832	41.54	0.0001	3.714	11.973	0.310
Daily activities (RE)	195	38.23	862	41.90	<0.0001	3.666	8.909	0.412
Emotional affect (MH)	198	38.56	866	41.40	0.0011	2.838	10.974	0.259
Energy (VT)	199	44.04	867	46.65	0.0004	2.612	9.205	0.284
General health (GH)	199	43.54	871	46.75	<0.0001	3.213	8.565	0.375
Pain (BP)	199	42.20	859	45.87	<0.0001	3.674	10.334	0.356
Physical problems (PF)	197	39.94	867	43.87	<0.0001	3.936	9.250	0.426
Social (SF)	198	38.63	861	42.81	<0.0001	4.172	9.948	0.419
Work (RP)	197	39.30	866	43.48	<0.0001	4.181	10.064	0.415
Notes: *CMD = Clinically meaningful differences. Patients with lipoatrophy had worse quality of life in both summary scores and in all eight individual questions, with the clinically meaningful differences ranging from 0.259–0.431 (small to medium)