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Review Article

Deconstructing autism: from unitary syndrome to contributory developmental endophenotypes

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Pages 18-24 | Received 31 Oct 2017, Accepted 22 Jan 2018, Published online: 02 Mar 2018

Figures & data

Figure 1. A developmental deconstruction of familial autism. Under this model, attempts to fractionate autism according to the traditional symptom triad (rather than by the orthogonal axes of neuropsychiatric liability indexed by A, B, C, and D) erode statistical power to link the autistic syndrome with genetic variants and other biological markers.

Figure 1. A developmental deconstruction of familial autism. Under this model, attempts to fractionate autism according to the traditional symptom triad (rather than by the orthogonal axes of neuropsychiatric liability indexed by A, B, C, and D) erode statistical power to link the autistic syndrome with genetic variants and other biological markers.