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Articles

Improvement in sleep and itch and enhanced quality of life in adult patients with moderate-to-severe atopic dermatitis: results from a phase 3 trial of baricitinib therapy

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Pages 2057-2062 | Received 31 Mar 2021, Accepted 02 Apr 2021, Published online: 28 Jun 2021

Figures & data

Table 1. Baseline demographic and clinical characteristics, overall and by itch and sleep improvement subgroups.

Figure 1. Proportion of patients with and without itch improvement achieving DLQI endpoints at Week 16. AD: atopic dermatitis; DLQI: Dermatology Life Quality Index. ***p < .0001. Itch improvement is defined as a ≥ 4-point decrease in the Itch Numeric Rating Scale at Week 16.

Figure 1. Proportion of patients with and without itch improvement achieving DLQI endpoints at Week 16. AD: atopic dermatitis; DLQI: Dermatology Life Quality Index. ***p < .0001. Itch improvement is defined as a ≥ 4-point decrease in the Itch Numeric Rating Scale at Week 16.

Figure 2. Mean change from baseline in work productivity and daily activity impairment in patients with and without itch improvement. Scores are from the Work Productivity and Activity Impairment Questionnaire – Atopic Dermatitis. ***p ≤ .0001. Itch improvement is defined as a ≥ 4-point decrease in the Itch Numeric Rating Scale at Week 16. Absenteeism, presenteeism, and overall work impairment were measured in employed patients only (n = 253).

Figure 2. Mean change from baseline in work productivity and daily activity impairment in patients with and without itch improvement. Scores are from the Work Productivity and Activity Impairment Questionnaire – Atopic Dermatitis. ***p ≤ .0001. Itch improvement is defined as a ≥ 4-point decrease in the Itch Numeric Rating Scale at Week 16. Absenteeism, presenteeism, and overall work impairment were measured in employed patients only (n = 253).

Figure 3. Proportion of patients with and without sleep improvement achieving DLQI endpoints at Week 16. AD, atopic dermatitis; DLQI, Dermatology Life Quality Index. ***p < .0001. Sleep improvement is defined as a ≥ 1.5-point decrease in Atopic Dermatitis Sleep Scale Item 2 score at Week 16.

Figure 3. Proportion of patients with and without sleep improvement achieving DLQI endpoints at Week 16. AD, atopic dermatitis; DLQI, Dermatology Life Quality Index. ***p < .0001. Sleep improvement is defined as a ≥ 1.5-point decrease in Atopic Dermatitis Sleep Scale Item 2 score at Week 16.

Figure 4. Mean change from baseline in work productivity and daily activity impairment in patients with and without sleep improvement. Scores are from the Work Productivity and Activity Impairment Questionnaire – Atopic Dermatitis. ***p < .0001. Sleep improvement is defined as a ≥ 1.5-point decrease in Atopic Dermatitis Sleep Scale Item 2 score at Week 16. Absenteeism, presenteeism, and overall work impairment were measured in employed patients only (n = 148).

Figure 4. Mean change from baseline in work productivity and daily activity impairment in patients with and without sleep improvement. Scores are from the Work Productivity and Activity Impairment Questionnaire – Atopic Dermatitis. ***p < .0001. Sleep improvement is defined as a ≥ 1.5-point decrease in Atopic Dermatitis Sleep Scale Item 2 score at Week 16. Absenteeism, presenteeism, and overall work impairment were measured in employed patients only (n = 148).