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Original Articles

The impact of supportive care on survival in large animal models of total body irradiation

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Pages S88-S99 | Received 25 Jun 2019, Accepted 17 Oct 2019, Published online: 21 Sep 2020

Figures & data

Table 1. Comparison of supportive care regimens (full, standard, limited) for minipigs and NHPs. Specific details on supportive care measures is provided in the Materials and Methods section.

Table 2. Study enrollment and survival outcome for each species and by level of supportive care.

Figure 3. Estimated percent lethality versus radiation dose based on a probit transformation of percent mortality based on the method of Miller and Tainter (Citation1944) for (a) Gottingen minipigs receiving standard supportive care (dotted line) versus limited supportive care (dashed line) following total body exposures to gamma irradiation; and (b) for NHPs receiving full supportive care (solid line), standard supportive care (dotted line) or limited supportive care (dashed line) following total body exposures to 6 MV photon irradiation.

Figure 3. Estimated percent lethality versus radiation dose based on a probit transformation of percent mortality based on the method of Miller and Tainter (Citation1944) for (a) Gottingen minipigs receiving standard supportive care (dotted line) versus limited supportive care (dashed line) following total body exposures to gamma irradiation; and (b) for NHPs receiving full supportive care (solid line), standard supportive care (dotted line) or limited supportive care (dashed line) following total body exposures to 6 MV photon irradiation.