Function of stem cells in radiation-induced damage

Abstract

Purpose

The aim of this review is to discuss previous studies on the function of stem cells in radiation-induced damage, and the factors affecting these processes, in the hope of improving our understanding of the different stem cells and the communication networks surrounding them. This is essential for the development of effective stem cell-based therapies to regenerate or replace normal tissues damaged by radiation.

Conclusion

In salivary glands, senescence-associated cytokines and inflammation-associated cells have a greater effect on stem cells. In the intestinal glands, Paneth cells strongly affect stem cell-mediated tissue regeneration after radiation treatment. In the pancreas, β-cells as well as protein C receptor positive (Procr) cells are expected to be key cells in the treatment of diabetes. In the bone marrow, a variety of cytokines such as CXC-chemokine ligand 12 (CXCL12) and stem cell factor (SCF), contribute to the functional recovery of hematopoietic stem cells after irradiation.

Keywords:

• Radiotherapy
• stem cells
• salivary glands
• intestinal glands
• pancreas
• hematopoietic stem cells (HSCs)

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.

Notes on contributors

Zheran Liu

Zheran Liu is a PhD student at West China Hospital of Sichuan University with an interest in radiation injury.

Liqiang Hu

Liqiang Hu works at West China Hospital of Sichuan University and is interested in radiation injuries.

Ling He

Ling He is a PhD student from West China Hospital of Sichuan University with an interest in radiation injury.

Lianlian Yang

Lianlian Yang is a master's student at West China Hospital of Sichuan University with an interest in radiation injury.

Zijian Qin

Zijian Qin is a master's student at West China Hospital of Sichuan University with an interest in radiation injury.

Yuping Xie

Yuping Xie works at Chengdu First People's Hospital and is interested in radiation-related injuries.

Xingchen Peng

Xingchen Peng works at West China Hospital of Sichuan University and is interested in radiation irradiation injuries.

Lei Dai

Lei Dai works at Sichuan University and is interested in radiation-related injuries.